Safety Issues of Chinese Medicine: A Review of Intoxication Cases in Hong Kong

NG Kit-ying; CHENG Chuen-lung; XU Hong-xi; NG Kit-ying; CHENG Chuen-lung; XU Hong-xi

Archive > Volume 1 Issue 1 > 2009,1(1):29-39. DOI:10.3969/j.issn.1674-6384.年份.期.第幾篇文章 Prev Next

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Safety Issues of Chinese Medicine: A Review of Intoxication Cases in Hong Kong

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摘要:

中藥在香港的應(yīng)用已有幾個世紀(jì)的歷史。實際上，大約60%的香港人使用中藥。然而，近年來，關(guān)于中藥中毒致死的報道越來越多。誤用有毒的或具有潛在毒性的中藥可以導(dǎo)致嚴(yán)重的中毒反應(yīng)。從該角度出發(fā)，本文綜述了發(fā)生在香港的中藥中毒事件，對中藥的毒性和副作用以及質(zhì)量控制也給出了深入的見解。通過提高對中藥毒性的認(rèn)知，可以更好地研究中藥毒性成分、機理及質(zhì)量控制。

Abstract:

Chinese medicine (CM) has been widely used in Hong Kong for centuries. In fact, CM practitioners currently provide over 20% of the medical consultations in Hong Kong and about 60% of the population has previously used CM. In 1999, the Legislative Council passed the Chinese Medicine Ordinance with aims to govern practice, use, trading, and manufacturing of CM in Hong Kong. While it is usually safe to use CM under proper application and guidance, there have been frequent reports on intoxication and fatalities. The misuse of potent/toxic CM, because of misidentification or overdose, can cause severe aconite, aristolochic acid, anticholinergic, podophyllin, grayanotoxin, pyrrolizidine alkaloids, matrine, gelsemine, teucvin, and strychnine poisoning. In this review, we summarized CM intoxication cases in Hong Kong, concentrating on the discussion of toxic and adverse effects as well as the quality control of CM. By increasing the awareness of CM toxicity, we hope to enhance the regulatory process and stimulate further research on their toxic dose, toxic ingredients, intoxication mechanisms, and quality control.

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