醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

Archive > Volume 8 Issue 4 > 2016,8(4):297-298. DOI:10.1016/S1674-6384(16)60054-0 Prev Next

Reviews

Chinmedomics Builds a Bridge from Traditional to Modern Research of Traditional Chinese Medicine

  • Article
  • Figures
  • Metrics
  • Preview PDF
  • Reference
  • Related
  • Cited by
  • Materials
    摘要:


    Abstract:
    Objective Pinoresinol di-glucopyranoside (PDG) is one of the main active lignans ingredients of Eucommiae Cortex considered to be a high-quality antihypertensive drug. In this study the pharmacokinetic process of PDG and its primary in vivo metabolite PG in the portal and jugular vein were surveyed and evaluated simultaneously. Methods A sensitive high-performance liquid chromatography coupled with tandem quadruple mass spectrometry (HPLC-MS/MS) method and sample preparation protocol were developed and validated in method of selectivity, sensitivity, precision, stability, and extraction recovery for the simultaneous determination of PDG and its primary metabolite pinoresinol glucoside (PG) in rat plasma.The double intubation technique was used to simultaneously collect blood from common jugular vein and hepatic portal vein after single ig administration of PDG. Results Using this method, the quantification linearity ranges of PDG and PG in rat plasma were both 0.05-100 ng/mL.This method was successfully applied to the evaluation of the absolute oral bioavailability of PDG and determination of the pharmacokinetic properties of PDG and PG after ig administration of single dose in rats. The bioavailability of PDG at common jugular vein ws 51.3% compared to that of 91.6% at hepatic portal vein. Conclusion We conclude that liver is the major conversion site of PDG to PG.

    關鍵詞:


    Keywords:


    Project Supported:
    Doctoral Fund of Ministry of Education of China (20131210120010); Important Drug Develop of MOST, China (2013ZX09401-004); Important Drug Develop of MOST, China (2012ZX09103201-046); Program for Innovative Research Team in Universities of Tianjin (TD12-5033, TD12-5036); Tianjin Science and Technology Innovation System and Conditions Platform Construction Plan (14TXZYJC00440)

    Clc Number:

WeChat

Mobile website