作為藥食兩用植物資源梔子世界范圍內(nèi)的應(yīng)用已有幾千年歷史。近年來(lái)，人們利用現(xiàn)代技術(shù)就梔子提取物及活性成分進(jìn)行了大量的研究，特別是對(duì)梔子抗氧化、抗炎、保肝、神經(jīng)保護(hù)、抗糖尿病以及抗腫瘤等活性研究取得了重要進(jìn)展。本文擬從梔子的植物鑒定、化學(xué)成分、藥理學(xué)和藥代動(dòng)力學(xué)、安全性和毒性評(píng)價(jià)以及臨床應(yīng)用等方面的研究進(jìn)展做一簡(jiǎn)單綜述。

Fruits of Gardenia jasminoides (Zhizi in Chinese) have been used as dietary supplement and traditional Chinese medicine for thousands of years. Recent studies on Gardenia jasminoides reveal that the extracts or the active components play an essential role in oxidative stress, inflammation, hepatoprotection, neuroprotection, anti-diabetes, antitumor and so on. Here, we reviewed G. jasminoides in the aspects of botanical identity, chemical ingredients, pharmacology and pharmacokinetics, safety and toxicity evaluation, clinical application, etc.

藏花素;梔子;京尼平苷;藥理學(xué)

Project Supported:

National Natural Science Foundation of China (81373459), Chongqing Science and Technology Committee (CSTC, 2015jcyjbx0064), Chongqing Science Found for Distinguished Young Scholars (2014jcyjjq10003), the Innovation of Science and Technology Leading Talent in Chongqing (2014kjcxljrc0018), and the Innovative Research Team Development Program at the University of Chongqing (CXTDX201601031)

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