0.05),血尿素氮 (MD = 0.25, 95%CI [0.23, 0.74], P > 0.05) 和內(nèi)源性肌酐清除率 (MD = 0.43, 95%CI [3.48, 2.62], P > 0.05) 無顯著性差異。雷公藤多苷聯(lián)合纈沙坦組不良反應(yīng)發(fā)生率明顯高于纈沙坦單藥治療組 (MD=3.41, 95%CI [1.34, 8.66], P < 0.05)。所納入的所有監(jiān)測指標(biāo)均不存在發(fā)表偏倚。 結(jié)論:雷公藤多苷聯(lián)合纈沙坦治療DN療效確切。然而,聯(lián)合治療的安全性有待進(jìn)一步證實。;Objective: Growing problem of antibiotic resistance in Helicobacter pylori, as a common cause of chronic gastritis and even stomach cancer, demands searching for novel candidates of herbal sources. This study is aimed at assessing the antimicrobial activity of aqueous extract obtained from Quercus brantii var. persica seed coat (Testa) on H. pylori isolated from gastric biopsy specimens. Methods: Such specimens were collected from 100 patients presenting with endoscopic gastroduodenal findings. Testa extracts were prepared from Persian Oak forests in the province of Kohgiluyeh and Boyer-Ahmad, IRAN. H. pylori isolates were obtained by a series of standard bacteriology tests and cell culture, then were confirmed by PCR. The activity of testa extracts towards 25 H. pylori isolates was assessed by well diffusion method, microdilution assay, and a disk diffusion assay in vitro. Results were analyzed statistically by one-way ANOVA analysis. Results: Aqueous extract of testa demonstrated an antimicrobial activity with zone diameters of inhibition ranged from 0 mm to 40 mm. Its inhibitory activity increased simultaneously with increasing extract concentration. The lowest MIC and MBC were both recorded as 2 μg/mL. Anti-H. pylori activity of testa extract was approximately close to tetracycline and metronidazole and less than amoxicillin. A potent extract of testa possessed significant inhibitory activity (P < 0.05). Conclusion: Testa extract is suggested as a natural therapeutic source against the gastric H. pylori infection. However, evaluating the in vivo activity of this extract is necessary too."/>