0.05)，血尿素氮 (MD = 0.25, 95%CI [0.23, 0.74], P > 0.05) 和內(nèi)源性肌酐清除率 (MD = 0.43, 95%CI [3.48, 2.62], P > 0.05) 無顯著性差異。雷公藤多苷聯(lián)合纈沙坦組不良反應(yīng)發(fā)生率明顯高于纈沙坦單藥治療組 (MD=3.41, 95%CI [1.34, 8.66], P < 0.05)。所納入的所有監(jiān)測指標(biāo)均不存在發(fā)表偏倚。 結(jié)論：雷公藤多苷聯(lián)合纈沙坦治療DN療效確切。然而，聯(lián)合治療的安全性有待進(jìn)一步證實。;Objective: Growing problem of antibiotic resistance in Helicobacter pylori, as a common cause of chronic gastritis and even stomach cancer, demands searching for novel candidates of herbal sources. This study is aimed at assessing the antimicrobial activity of aqueous extract obtained from Quercus brantii var. persica seed coat (Testa) on H. pylori isolated from gastric biopsy specimens. Methods: Such specimens were collected from 100 patients presenting with endoscopic gastroduodenal findings. Testa extracts were prepared from Persian Oak forests in the province of Kohgiluyeh and Boyer-Ahmad, IRAN. H. pylori isolates were obtained by a series of standard bacteriology tests and cell culture, then were confirmed by PCR. The activity of testa extracts towards 25 H. pylori isolates was assessed by well diffusion method, microdilution assay, and a disk diffusion assay in vitro. Results were analyzed statistically by one-way ANOVA analysis. Results: Aqueous extract of testa demonstrated an antimicrobial activity with zone diameters of inhibition ranged from 0 mm to 40 mm. Its inhibitory activity increased simultaneously with increasing extract concentration. The lowest MIC and MBC were both recorded as 2 μg/mL. Anti-H. pylori activity of testa extract was approximately close to tetracycline and metronidazole and less than amoxicillin. A potent extract of testa possessed significant inhibitory activity (P < 0.05). Conclusion: Testa extract is suggested as a natural therapeutic source against the gastric H. pylori infection. However, evaluating the in vivo activity of this extract is necessary too."/>

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Archive > Volume 11 Issue 4 > 2019,11(4):429-433. DOI:10.1016/j.chmed.2019.09.004 Prev Next

雷公藤多苷聯(lián)合纈沙坦治療糖尿病腎病的系統(tǒng)回顧和薈萃分析

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In vivo investigation of antimicrobial effects of cinnamaldehyde using immunosuppressed ICR mice with invasive pulmonary aspergillosis

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    摘要:
    目的：評價雷公藤多苷聯(lián)合纈沙坦治療糖尿病腎病（DN）的療效和安全性。 方法：本文對12個電子數(shù)據(jù)庫進(jìn)行綜合研究。被納入的研究分別由兩位作者獨立使用Review Manager（版本5.2）和Stata（版本12.0）進(jìn)行提取和分析。 結(jié)果：共納入12項隨機(jī)對照試驗，涉及829例患者。結(jié)果表明，聯(lián)合用藥能顯著提高DN患者的總有效率（RR = 1.35, 95%CI [1.22, 1.50], P < 0.001）及血清白蛋白水平（平均差（MD） = 3.87, 95%CI [3.12, 4.62], P < 0.001），并顯著降低24小時尿蛋白水平 (MD = 0.97, 95%CI [1.19, 0.76], P < 0.001）、尿白蛋白排泄率 (MD = 145.53, 95%CI [227.95, 63.11], P < 0.001）及尿β2微球蛋白水平 (MD = 11.86, 95%CI [13.02, 10.69], P < 0.001)。血清肌酐 (MD = 0.26, 95%CI [7.52, 7.00], P > 0.05)，血尿素氮 (MD = 0.25, 95%CI [0.23, 0.74], P > 0.05) 和內(nèi)源性肌酐清除率 (MD = 0.43, 95%CI [3.48, 2.62], P > 0.05) 無顯著性差異。雷公藤多苷聯(lián)合纈沙坦組不良反應(yīng)發(fā)生率明顯高于纈沙坦單藥治療組 (MD=3.41, 95%CI [1.34, 8.66], P < 0.05)。所納入的所有監(jiān)測指標(biāo)均不存在發(fā)表偏倚。 結(jié)論：雷公藤多苷聯(lián)合纈沙坦治療DN療效確切。然而，聯(lián)合治療的安全性有待進(jìn)一步證實。

    Abstract:
    Objective: Growing problem of antibiotic resistance in Helicobacter pylori, as a common cause of chronic gastritis and even stomach cancer, demands searching for novel candidates of herbal sources. This study is aimed at assessing the antimicrobial activity of aqueous extract obtained from Quercus brantii var. persica seed coat (Testa) on H. pylori isolated from gastric biopsy specimens. Methods: Such specimens were collected from 100 patients presenting with endoscopic gastroduodenal findings. Testa extracts were prepared from Persian Oak forests in the province of Kohgiluyeh and Boyer-Ahmad, IRAN. H. pylori isolates were obtained by a series of standard bacteriology tests and cell culture, then were confirmed by PCR. The activity of testa extracts towards 25 H. pylori isolates was assessed by well diffusion method, microdilution assay, and a disk diffusion assay in vitro. Results were analyzed statistically by one-way ANOVA analysis. Results: Aqueous extract of testa demonstrated an antimicrobial activity with zone diameters of inhibition ranged from 0 mm to 40 mm. Its inhibitory activity increased simultaneously with increasing extract concentration. The lowest MIC and MBC were both recorded as 2 μg/mL. Anti-H. pylori activity of testa extract was approximately close to tetracycline and metronidazole and less than amoxicillin. A potent extract of testa possessed significant inhibitory activity (P < 0.05). Conclusion: Testa extract is suggested as a natural therapeutic source against the gastric H. pylori infection. However, evaluating the in vivo activity of this extract is necessary too.

    關(guān)鍵詞:
    糖尿病腎病;薈萃分析;雷公藤多苷;纈沙坦

    Keywords:


    Project Supported:
    This work has received research grant support (MICRO_96_A2) from Yasuj University of Medical Sciences. This work was supported by Yasuj University of Medical Sciences, Yasuj, Iran.

    Clc Number:

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