Network tocicolgy and LC-MS-based metabolomics: New approaches for mechnanism of action of toxic components in traditional Chinese medicines

Xin-yu Li; Xin Jin; Ya-zhuo Li; Dan-dan Gao; Rui Liu; Chang-xiao Liu; Xin-yu Li; Xin Jin; Ya-zhuo Li; Dan-dan Gao; Rui Liu; Chang-xiao Liu

Archive > Volume 11 Issue 4 > 2019,11(4):357-363. DOI:10.1016/j.chmed.2019.02.002 Prev Next

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Network tocicolgy and LC-MS-based metabolomics: New approaches for mechnanism of action of toxic components in traditional Chinese medicines

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摘要:

Abstract:

Network toxicology combined with metabonomics is of great significance for the study of the toxic mechanism and prediction of toxicity of traditional Chinese medicines (TCMs). In this study, we reviewed the application of network toxicology based on LC-MS metabolomics, mainly in the study of toxic components and the toxicity mechanism of TCMs, which provides new ideas and methods for the further study of the toxicity mechanism of TCMs.

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National Science Foundation for Post-doctoral (2015M570231), Science and Technology Program of Tianjin (15PTCYSY00030), and National Key research and development program (2016YFE0121400)

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