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Archive > Volume 15 Issue 1 > 2023,15(1):151-154. DOI:https://doi.org/10.1016/j.chmed.2021.12.007 Prev Next

野甘草地上部分化學(xué)成分研究

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Chemical constituents from aerial parts of Scoparia dulcis

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    摘要:
    目的: 研究野甘草地上部分的化學(xué)成分。 方法: 采用多種色譜技術(shù)進行分離純化，并通過波譜手段結(jié)合文獻數(shù)據(jù)鑒定化合物結(jié)構(gòu)。通過a-葡萄糖苷酶抑制活性測定挖掘潛在的a-葡萄糖苷酶抑制劑。 結(jié)果: 從野甘草地上部分分離鑒定了9個化合物。結(jié)構(gòu)鑒定為Scoparic zolone (1), (2S)-2,7-二羥基-2H-1,4-苯并噁嗪-3(4H)-酮(2), (2R)-7-羥基-2H-1,4-苯并噁嗪-3(4H)-酮-2-O-β-D-吡喃葡萄糖苷(3), (2R)-7-甲氧基-2H-1,4-苯并噁嗪-3(4H)-酮-2-O-β-D-吡喃葡萄糖苷(4), (2S)-7-羥基-2H-1,4-苯并噁嗪-3(4H)-酮-2-O-β-D-吡喃葡萄糖苷(5), 6-甲氧基-苯并噁唑啉-2(3H)-酮(6), 4-乙?；?3,5-二甲氧基對羥基喹啉 (7), 無刺棗催吐醇苷I (8) 和 3,4-二羥基苯乙酸 (9)?；衔?具有顯著的a-葡萄糖苷酶抑制活性，其IC50值為132.8 ± 11.5 μmol/L，是陽性藥阿卡波糖的28倍。 結(jié)論:化合物1為一個新的天然產(chǎn)物?；衔?和9為首次從野甘草屬中分離得到?；衔?, 5, 7, 8為首次從玄參科中分離得到。

    Abstract:
    Objective: To study the chemical constituents from the aerial parts of Scoparia dulcis. Methods: Various chromatographic techniques were used to separate the constituents and their structures were elucidated using spectroscopic methods and by comparing their data to those reported in the literatures. The α-glucosidase inhibitory activity assay was used to identify potential α-glucosidase inhibitors. Results: Nine compounds were isolated from the aerial parts of S. dulcis. Their structures were identified as Scoparic zolone (1), (2S)-2,7-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (2), (2R)-7-hydroxy-2H-1,4- benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside (3), (2R)-7-methoxy-2H-1,4-benzoxazin-3(4H)-one-2- O-β-D-glucopyranoside (4), (2S)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside (5), 6-methoxy-benzoxazolin-2(3H)-one (6), 4-acetonyl-3,5-dimethoxy-p-quinol (7), zizyvoside I (8), and 3,4-dihydroxy benzeneacetic acid (9). Compound 2 showed the potent α-glucosidase inhibitory activity with an IC50 value of (132.8 ± 11.5) lmol/L, which is 28-fold higher than the positive control acarbose. Conclusion: Compound 1 is a new natural product. Compounds 2 and 9 have not been reported in Scoparia before. Compounds 3, 5, 7, 8 are isolated from Scrophulariaceae for the first time.

    關(guān)鍵詞:
    生物堿;化學(xué)成分;野甘草;α-葡萄糖苷酶抑制活性

    Keywords:


    Project Supported:
    We are thankful for financial supports from the National Natural Science Foundation of China (32170402, 81703682, 81874335).

    Clc Number:

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