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Archive > Volume 15 Issue 2 > 2023,15(2):157-168. DOI:https://doi.org/10.1016/j.chmed.2022.06.014 Prev Next

新冠病毒（COVID-19）感染機(jī)制和治療靶點(diǎn)的新觀點(diǎn)：三方三藥的治療前景

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New insights for infection mechanism and potential targets of COVID19: Three Chinese patent medicines and three Chinese medicine formulas as promising therapeutic approaches

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    摘要:
    由嚴(yán)重急性呼吸綜合征2型冠狀病毒(SARS-CoV-2)引起的新型冠狀病毒肺炎(COVID-19)具有高致病性和傳染性，已成為一種全球性的突發(fā)性致命流行病。目前尚無公認(rèn)的治療COVID-19的特效藥物。因此，明確COVID-19的致病機(jī)制，開發(fā)有效的治療方法迫在眉睫。根據(jù)來自中國的臨床病例報(bào)告，中藥，尤其是三方三藥，無論單獨(dú)使用還是與他藥聯(lián)使，都能有效緩解新冠癥狀。本文系統(tǒng)總結(jié)和分析了新冠發(fā)病機(jī)制及其中三方三藥的相關(guān)臨床報(bào)道、有效成分分析、網(wǎng)絡(luò)藥理學(xué)預(yù)測(cè)和潛在治療機(jī)制驗(yàn)證。此外，我們還總結(jié)了新冠肺炎常用處方中的高頻藥物，并對(duì)其調(diào)控機(jī)制進(jìn)行探討，冀為新冠肺炎新藥開發(fā)提供指導(dǎo)。我們認(rèn)為，通過共同應(yīng)對(duì)諸如藥物和配方有效成分復(fù)雜和治療靶點(diǎn)不清晰等重大挑戰(zhàn)，中醫(yī)藥將成為有前景且有效的針對(duì)COVID-19及相關(guān)流行病的防控和治療手段。

    Abstract:
    The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide. Currently, there is no accepted specific drug for COVID-19 treatment. Therefore, it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with COVID-19. According to several reliable reports from China, traditional Chinese medicine (TCM), especially for three Chinese patent medicines and three Chinese medicine formulas, has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western medicines. In this review, we systematically summarized and analyzed the pathogenesis of COVID-19, the detailed clinical practice, active ingredients investigation, network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 combat. Additionally, we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism, which provides guidance for the development of new drugs against COVID-19. Collectively, by addressing critical challenges, for example, unclear targets and complicated active ingredients of these medicines and formulas, we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.

    關(guān)鍵詞:
    COVID-19;化濕敗毒方;金花清感顆粒;連花清瘟膠囊;清肺排毒方;SARS-CoV-2;中醫(yī)藥; 宣肺敗毒方;血必凈注射液

    Keywords:


    Project Supported:
    This work was supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No. ZYYCXTD-C-202006 to XG and XL); Beijing Municipal Science & Technology Commission (No. 7212174 to XL); National Natural Science Foundation of China (No. 82004045 to XL); Beijing Nova Program of Science & Technology (No. Z191100001119088 to XL); and the Young Talents Promotion Project of China Association of Traditional Chinese Medicine (No. 2020-QNRC2-01 to XL).

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