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Archive > Volume 15 Issue 2 > 2023,15(2):222-230. DOI:https://doi.org/10.1016/j.chmed.2022.08.011 Prev Next

昆仙膠囊在臨床應(yīng)用中的藥理作用及其不良反應(yīng)研究綜述

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Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review

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    摘要:
    昆仙膠囊（KX）是中國傳統(tǒng)中藥，用于治療類風(fēng)濕關(guān)節(jié)炎、腎病綜合征、系統(tǒng)性紅斑狼瘡、過敏性紫癜、強(qiáng)直性脊柱炎、銀屑病關(guān)節(jié)炎和濕疹等。但目前關(guān)于昆仙膠囊的臨床應(yīng)用和不良反應(yīng)缺乏全面系統(tǒng)的文獻(xiàn)綜述。因此，本文對PubMed、China National Knowledge Infrastructure和萬方數(shù)據(jù)庫報(bào)道的昆仙膠囊藥理作用、臨床應(yīng)用及其不良反應(yīng)的相關(guān)文獻(xiàn)進(jìn)行了較為詳細(xì)的總結(jié)和論述。這些文獻(xiàn)由兩位作者獨(dú)立收集，時(shí)間不限，文獻(xiàn)截止日期為2022年11月30日。檢索詞包括昆仙膠囊及/或臨床療效、藥理、疾病、治療、不良反應(yīng)和質(zhì)量控制。昆仙膠囊已被證明可通過抑制炎癥反應(yīng)和誘導(dǎo)凋亡來有效治療自身免疫性關(guān)節(jié)炎。研究表明昆仙膠囊具有抗炎和鎮(zhèn)痛作用，可改善關(guān)節(jié)功能。昆仙膠囊具有祛風(fēng)除濕，補(bǔ)腎通絡(luò)的作用，可治療多種疾病。但也有研究表明昆仙膠囊對多個(gè)系統(tǒng)具有副作用。綜上所述，本文重點(diǎn)綜述了昆仙膠囊在治療或預(yù)防多種疾病中的應(yīng)用，為深入研究和拓展其臨床應(yīng)用提供了新思路。

    Abstract:
    Kunxian Capsule (KX) is a popular Chinese patent medicine for the treatment of rheumatoid arthritis, nephrotic syndrome, systemic lupus erythematosus, Henoch-Sch?nlein purpura, ankylosing spondylitis, psoriatic arthritis and eczema. However, there is scarcity of comprehensive information on the significance of KX in the clinical application and its side effects. Hence, it is aimed to provide a review of the significance of KX, with a focus on the pharmacological effects, clinical applications, and its adverse reactions. This review was based on the published literatures in PubMed, China National Knowledge Infrastructure and WanFang database. The articles were collected by two independent authors with no time limits applied until November 30, 2022. The search term includes Kunxian Capsule and/or clinical effect, pharmacology, disease, therapy, adverse effects and quality control. KX has been shown to be effective in the treatment of autoimmune arthritis by inhibiting inflammatory responses and inducing apoptosis. Many studies suggest that KX has anti-inflammatory and analgesic properties that aid in the improvement of joint functions. KX dispels wind, removes dampness, invigorates the kidneys, and promotes blood circulation, thereby curing various diseases. However, studies also suggest KX-related adverse reactions in multiple systems. Overall, this review highlights the scientific basis of KX in curing or preventing various diseases and provides novel insights for further research and clinical applications.

    關(guān)鍵詞:
    不良反應(yīng);自身免疫性疾病;草藥;昆仙膠囊;類風(fēng)濕性關(guān)節(jié)炎

    Keywords:


    Project Supported:
    This study was supported by Taishan Scholars Program (tsqn202211204), National Key R&D Program of China (2018YFC1707300), Shandong Provincial Natural Science Foundation (ZR2020YQ60), Jinan Talent Project for University (2021GXRC047), Science, Education and Industry Integration Innovation Pilot Project of Qilu University of Technology (Shandong Academy of Sciences) (2022PYI016).

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