Three new sesquiterpenes from roots of Curcuma longa

doi:https://doi.org/10.1016/j.chmed.2022.11.007

Archive > Volume 15 Issue 3 > 2023,15(3):470-474. DOI:https://doi.org/10.1016/j.chmed.2022.11.007 Prev Next

來自于姜黃根中的三個新的倍半萜

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Three new sesquiterpenes from roots of Curcuma longa

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摘要:

目的：研究姜黃根的化學成分。方法：通過廣泛的光譜分析，包括1D和2D NMR, MS, UV和CD分析，闡明新化合物的結構。結果：利用95%乙醇(體積百分比)將兩個新倍半萜烯化合物(1S,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (1), (1R,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (2),和一個新的天然產物6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one (3)與三個已知化合物芳姜黃酮(4)，2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (5)和2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (6)從姜黃根中提取分離。結論：從姜黃中分離得到3個新的化合物，并確定了它們的絕對構型。

Abstract:

Objective: To study the chemical constituents from the roots of Curcuma longa. Methods: The structures of the new compounds were elucidated based on extensive spectral analysis, including 1D and 2D NMR, MS, UV, and CD analysis. Results: Two new sesquiterpene compounds (1S,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (1), (1R,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (2), and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one (3) together with three known compounds ar-turmerone (4), 2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (5) and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (6) were isolated from C. longa root extract with 95% ethanol. Conclusion: In the study, three new compounds were isolated from C. longa, and their absolute configurations were determined.

關鍵詞:

姜黃;化學成分;姜黃素;核磁共振;倍半萜

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Project Supported:

Sub-project of National Basic Science Talent Training Fund (No. J1103606).

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