Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke

doi:https://doi.org/10.1016/j.chmed.2023.09.003

Archive > Volume 15 Issue 4 > 2023,15(4):496-508. DOI:https://doi.org/10.1016/j.chmed.2023.09.003 Prev Next

中醫(yī)藥防治缺血性腦卒中的藥效學(xué)優(yōu)勢(shì)和特點(diǎn)

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Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke

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摘要:

缺血性腦卒中（Ischemic stroke, IS）是一種嚴(yán)重的腦血管疾病，發(fā)病率、致殘率和死亡率都很高。重組組織纖溶酶原激活劑（Recombinant tissue plasminogen activator, r-tPA）是IS的一線(xiàn)治療藥物。然而，由于治療窗口期較窄，且存在出血風(fēng)險(xiǎn)，致使許多患者難以獲得有效治療。中醫(yī)藥在預(yù)防和治療 IS 方面具有明顯優(yōu)勢(shì)。中醫(yī)藥能夠增強(qiáng)腦微循環(huán)、緩解神經(jīng)功能紊亂、調(diào)節(jié)能量代謝、減輕炎癥反應(yīng)、抑制氧化應(yīng)激損傷和細(xì)胞凋亡，從而減輕腦損傷和預(yù)防IS復(fù)發(fā)。本文從中醫(yī)角度總結(jié)了IS的病因、病機(jī)、治療策略以及與現(xiàn)代生物學(xué)的關(guān)系，詳細(xì)討論了中醫(yī)藥防治IS的優(yōu)勢(shì)，并進(jìn)一步綜述了中醫(yī)藥在IS急性期、恢復(fù)期以及中風(fēng)后并發(fā)癥中的藥效學(xué)特點(diǎn)和優(yōu)勢(shì)。這為中醫(yī)藥防治在 IS的臨床應(yīng)用以及新型藥物的開(kāi)發(fā)提供了寶貴的見(jiàn)解和參考。

Abstract:

Ischemic stroke (IS) is a severe cerebrovascular disease with a high incidence, mortality, and disability rate. The first-line treatment for IS is the use of recombinant tissue plasminogen activator (r-tPA). Regrettably, numerous patients encounter delays in treatment due to the narrow therapeutic window and the associated risk of hemorrhage. Traditional Chinese medicine (TCM) has exhibited distinct advantages in preventing and treating IS. TCM enhances cerebral microcirculation, alleviates neurological disorders, regulates energy metabolism, mitigates inflammation, reduces oxidative stress injuries, and inhibits apoptosis, thereby mitigating brain damage and preventing IS recurrence. This article summarizes the etiology, pathogenesis, therapeutic strategies, and relationship with modern biology of IS from the perspective of TCM, describes the advantages of TCM in the treatment of IS, and further reviews the pharmacodynamic characteristics and advantages of TCM in the acute and recovery phases of IS as well as in post-stroke complications. Additionally, it offers valuable insights and references for the clinical application of TCM in IS prevention and treatment, as well as for the development of novel drugs.

關(guān)鍵詞:

缺血性腦卒中;二級(jí)預(yù)防;辨證論治;中醫(yī)藥;中醫(yī)藥優(yōu)勢(shì)病種

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This study was supported by the National Natural Science Foundation of China (No. 82174112), and the Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (No.22HHZYSS00015).

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