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Archive > Volume 15 Issue 4 > 2023,15(4):526-532. DOI:https://doi.org/10.1016/j.chmed.2023.09.001 Prev Next

中草藥治療尿路結(jié)石研究進(jìn)展

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Therapeutic effects of Chinese herbal medicines for treatment of urolithiasis: A review

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    摘要:
    尿路結(jié)石是泌尿系統(tǒng)的一種常見(jiàn)而復(fù)雜的疾病，可誘發(fā)輸尿管堵塞和尿路感染，甚者可造成泌尿器官的損傷。雖然尿路結(jié)石可以被治愈，但是其高復(fù)發(fā)率和存在發(fā)展為慢性腎臟的風(fēng)險(xiǎn)引起了腎臟病專(zhuān)家的注意。雖然體外碎石、經(jīng)皮腎鏡取石術(shù)等微創(chuàng)技術(shù)的應(yīng)用提高了尿路結(jié)石的治愈率，但藥物治療在降低其發(fā)病率和復(fù)發(fā)率方面發(fā)揮著不可或缺的作用。在發(fā)展中國(guó)家，中醫(yī)藥用于治療和預(yù)防泌尿系結(jié)石已有數(shù)百年的歷史，其療效和安全性毋庸置疑。本文回顧了中草藥治療尿路結(jié)石的臨床試驗(yàn)和藥理研究進(jìn)展。中草藥治療尿路結(jié)石的機(jī)制包括阻止結(jié)石的進(jìn)一步生長(zhǎng)和聚集、降低尿液PH值和促進(jìn)結(jié)石的溶解。另外一些中草藥可以增加排尿量，放松平滑肌，促進(jìn)結(jié)石排出。這些發(fā)現(xiàn)為治療尿路結(jié)石和繼發(fā)性腎損傷提供了新的治療策略。

    Abstract:
    Urolithiasis is a common and complex disease of the urinary system, which can cause urinary tract blockage, urinary tract infection, and even damage to urinary system-related tissues. Although urolithiasis can be cured, its high recurrence rate and the development of chronic kidney disease in some patients have drawn the attention of nephrologists. Although the application of extracorporeal lithotripsy, percutaneous nephrolithotomy and other minimally invasive techniques have made the treatment of urolithiasis more efficient, pharmacotherapy plays an indispensable role in reducing their morbidity and recurrence rates. Traditional Chinese medicine (TCM) has been used for treatment and prevention of urolithiasis in developing countries for centuries, known for its unquestionable efficacy and safety. This article reviews the progress of clinical trials and pharmacological studies on the treatment of urolithiasis with Chinese herbal medicines (CHMs). The mechanism of CHMs in the treatment of urolithiasis mainly involve preventing further growth and aggregation of urolithiasis, reducing the PH of urine, promoting calculus dissolution. Furthermore, some CHMs can increase urine output, relax smooth muscles, and promote the removal of calculus. These findings provide new treatment strategies and options for urolithiasis and secondary kidney damage.

    關(guān)鍵詞:
    中草藥;慢性腎臟病;機(jī)制;藥理學(xué);尿路結(jié)石

    Keywords:


    Project Supported:
    This work was supported by Tianjin municipal health and health committee high-level talent project (No. TJSQNYXXR-D2-138).

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