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Archive > Volume 17 Issue 1 > 2025,17(1):31-40. DOI:https://doi.org/10.1016/j.chmed.2024.04.005 Prev Next

基于質(zhì)譜成像技術(shù)的中藥質(zhì)量標(biāo)志物發(fā)現(xiàn)與應(yīng)用

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Mass spectrometry imaging for unearthing and validating quality markers in traditional Chinese medicines

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    摘要:
    中藥質(zhì)量標(biāo)志物是中藥質(zhì)量控制的新概念、新模式，將引領(lǐng)中藥質(zhì)量發(fā)展新方向。其中，如何表征中藥整體質(zhì)量屬性及其生物學(xué)效應(yīng)，是質(zhì)量標(biāo)志物研究的關(guān)鍵科學(xué)問題。針對(duì)此關(guān)鍵科學(xué)問題，本文提出基于質(zhì)譜成像技術(shù)（MSI）的研究方法，以發(fā)現(xiàn)和確證中藥質(zhì)量標(biāo)志物。MSI是整合了質(zhì)譜分析和可視化成像分析的新型技術(shù)方法，能夠以高空間和高質(zhì)量分辨率對(duì)組織或者細(xì)胞中的成分進(jìn)行可視化。在此基礎(chǔ)上，基于中藥質(zhì)量標(biāo)志物確證的五原則，即特異性、有效性、傳遞與溯源、可測(cè)性和處方配伍，對(duì)候選中藥質(zhì)量標(biāo)志物進(jìn)行確證。

    Abstract:
    Quality marker (Q-Marker) is an innovative concept and model for quality control of Traditional Chinese medicines (TCMs), which will navigate the new direction of quality development of TCMs. Yet, how to characterize the overall quality attributes of TCMs and their biological effects is still debating. In view of this key scientific issue, this paper proposes a research method based on mass spectrometry imaging (MSI) technology for the discovery and confirmation of TCMs Q-Marker. MSI is powerful in investigating the spatial distribution of molecules in a variety of samples, and visualizing the information obtained from MS. On this basis, combine with the five principles of TCMs Q-Marker validation, i.e., specificity, transmission and traceability, testability, prescription compatibility, and validity, were applied to confirm the finalized Q-Marker. It will lead the new direction of quality development of TCMs.

    關(guān)鍵詞:
    五原則;質(zhì)量標(biāo)志物;質(zhì)量控制;中藥

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    Project Supported:
    This work was sponsored by the National Natural Science Foundation of China (No. 82303681 & 82202950), the Fundamental Research Funds for the Central Universities (No. 3332022063), and the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (No. 2021-I2M-1-042).

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