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Archive > Volume 17 Issue 2 > 2025,17(2):246-260. DOI:https://doi.org/10.1016/j.chmed.2025.01.003 Prev Next

從實驗證據(jù)和臨床應(yīng)用的角度，系統(tǒng)綜述中藥通過調(diào)節(jié)鐵死亡治療慢性疾病

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A systematical review on traditional Chinese medicine treating chronic diseases via regulating ferroptosis from the perspective of experimental evidence and clinical application

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    摘要:
    摘要：鐵死亡是一種獨特的細(xì)胞死亡調(diào)控形式，有別于細(xì)胞凋亡、細(xì)胞壞死和其他特征明確的細(xì)胞死亡調(diào)控類型，在糖尿病、高血壓、高脂血癥和非酒精性脂肪性肝炎等慢性代謝性疾病的發(fā)生和發(fā)展中發(fā)揮著重要作用。最近，越來越多的證據(jù)支持傳統(tǒng)中醫(yī)藥通過介導(dǎo)鐵死亡成為治療慢性代謝性疾病的新熱點。遺憾的是，很少有系統(tǒng)性綜述去描述中醫(yī)藥通過鐵死亡途徑治療慢性代謝性疾病的重要性。本綜述總結(jié)了鐵死亡的發(fā)生機制以及鐵死亡在慢性代謝性疾病中的作用。此外，本綜述還根據(jù)實驗證據(jù)和臨床應(yīng)用說明，中醫(yī)藥對鐵死亡的調(diào)控可能是治療慢性代謝性疾病的有效方法?？傊@項工作將提高人們對鐵死亡的認(rèn)識，以及中藥在慢性代謝性疾病中調(diào)節(jié)鐵死亡的能力，從而促進天然中藥的開發(fā)和應(yīng)用。

    Abstract:
    Ferroptosis is a unique regulated form of cell death that is distinct from apoptosis, necrosis, and other well-characterized regulated cell death types, and plays an important role in the occurrence and development of chronic metabolic diseases, including diabetes, hypertension, hyperlipidemia, and nonalcoholic steatohepatitis. Recently, increasing evidence has supported traditional Chinese medicine (TCM) as a new hot spot for the treatment of chronic metabolic diseases by mediating ferroptosis. Unfortunately, few systematic reviews have described the importance of TCM in treating chronic metabolic diseases through the ferroptosis pathway. In the current review, the mechanism of ferroptosis and the roles of ferroptosis in chronic metabolic diseases are summarized. Additionally, this review illustrates that the regulation of ferroptosis by TCM could be an effective approach for treating chronic metabolic diseases based on experimental evidence and clinical application. In summary, this work will improve the understanding of ferroptosis and the ability of TCM to regulate ferroptosis in chronic metabolic diseases, thereby promoting the development and application of natural TCM.

    關(guān)鍵詞:
    慢性代謝性疾病;糖尿病;鐵死亡;高脂血癥;高血壓;中藥

    Keywords:


    Project Supported:
    This work was financially supported by the National Key Research and Development Program of China (No. 2018YFC1707100), the Chief Scientist of Qi-Huang Project of National Traditional Chinese Medicine Inheritance and Innovation ‘‘One Hundred Million” Talent Project (2021); the Qi-Huang Scholar of National Traditional Chinese Medicine Leading Talents Support Program (2018); Heilongjiang Touyan Innovation Team Program (2019); the National Famous Old Traditional Chinese Medicine Experts Inheritance Studio Construction Program of National Administration of TCM (Grant Number: [2022] No. 75); and the Seventh Batch of National Famous Old Traditional Chinese Medicine Experts Experience Heritage Construction Program of National Administration of TCM (Grant Number: [2022] No. 76).

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