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Archive > Volume 17 Issue 3 > 2025,17(3):428-447. DOI:https://doi.org/10.1016/j.chmed.2025.04.006 Prev Next

莪術(shù)：抗癌中藥

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Curcumae Rhizoma: An anti-cancer traditional Chinese medicine

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    摘要:
    莪術(shù)（Curcumae Rhizoma）為姜科植物蓬莪術(shù)（Curcuma phaeocaulis）、廣西莪術(shù)（Curcuma kwangsiensis）或溫郁金（Curcuma wenyujin）的干燥根莖。傳統(tǒng)水煎法等制備的莪術(shù)混合提取物雖顯示出顯著抗癌作用，但因成分復(fù)雜導(dǎo)致其作用機(jī)制尚未明確?，F(xiàn)代研究者通過分離莪術(shù)單體成分進(jìn)行實(shí)驗(yàn)驗(yàn)證，發(fā)現(xiàn)莪術(shù)醇（curcumol）、吉馬酮（germacrone）、β-欖香烯（b-elemene）及姜黃素（curcumin）等活性成分在抗癌領(lǐng)域具有顯著調(diào)控作用。藥理學(xué)研究表明，莪術(shù)可通過抑制腫瘤細(xì)胞增殖、侵襲與遷移，誘導(dǎo)細(xì)胞凋亡及調(diào)控自噬等途徑發(fā)揮抗癌功效。本文系統(tǒng)綜述2013-2022年間莪術(shù)抗癌作用的研究進(jìn)展，旨在深入探索莪術(shù)活性成分抗腫瘤的分子機(jī)制。

    Abstract:
    Curcumae Rhizoma, derived from the rhizome of Curcuma phaeocaulis, Curcuma kwangsiensis and Curcuma wenyujin, was called Ezhu in China. In the past, Curcumae Rhizoma extracts were obtained through water decoction or alternative methods, which showed significant anti-cancer effects. However, the mixed extracts contain various compound components of Curcumae Rhizoma, leading to an ambiguous mechanism of action for Curcumae Rhizoma extracts anti-cancer. Contemporary researchers have extracted the chemical components of Curcumae Rhizoma separately for experimental verification of its active ingredients in the anti-cancer field. Numerous studies demonstrated that curcumol, germacrone, b-elemene, and curcumin in Curcumae Rhizoma extracts have significant governing effects in anti-cancer activities. Pharmacological studies have shown that Curcumae Rhizoma suppresses cancer cell proliferation, invasion, and migration, triggering apoptosis and regulating cellular autophagy to achieve anticancer effects. Here, we summarized the research progress of Curcumae Rhizoma on anti-cancer effects from 2013 to 2022, aiming to explore the deeper molecular mechanisms of Curcumae Rhizoma’s active components in cancer treatment.

    關(guān)鍵詞:
    癌癥;莪術(shù);姜黃素;莪術(shù)醇;吉馬酮;中藥;β-欖香烯

    Keywords:


    Project Supported:
    This work was supported by the Guangxi Science and Technology Major Project (No. GUIKE AA22096029 and No. AA23023035), and Macao Young Scholars Program (No. AM2022022). Furthermore, we would like to acknowledge and thank Prof. Jiagang Deng, Prof. Kenan Huang, and Prof. Liying Yu for providing Curcumae Rhizoma and their original plant photos.

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