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Archive > Volume 17 Issue 3 > 2025,17(3):464-472. DOI:https://doi.org/10.1016/j.chmed.2025.04.007 Prev Next

中醫(yī)藥調(diào)控腸道菌群治療冠心病的研究進展

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Research progress of regulating intestinal flora by traditional Chinese medicine in treating coronary heart disease

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    摘要:
    冠狀動脈粥樣硬化性心臟病是由動脈粥樣硬化引起的原發(fā)性心血管疾病，其特征是慢性炎癥和脂質(zhì)代謝異常。腸道菌群在人類健康和疾病中起著關(guān)鍵作用，研究表明腸道菌群代謝與冠心病的發(fā)生發(fā)展有著密切的聯(lián)系。本文就腸道菌群與冠心病之間的聯(lián)系及中醫(yī)藥調(diào)控腸道菌群治療冠心病的作用機制進行綜述，系統(tǒng)闡述了腸道菌群及其代謝產(chǎn)物與冠心病的關(guān)系?？偨Y(jié)近年來中醫(yī)藥調(diào)節(jié)腸道菌群改善冠心病的研究進展，為探索腸道菌群與冠心病的關(guān)系及冠心病的中醫(yī)藥治療方法提供更多參考和思路。

    Abstract:
    Coronary atherosclerotic heart disease is a major cardiovascular condition driven by atherosclerosis, distinguished by chronic inflammation and dysregulated lipid metabolism. The gut microbiota plays an essential role in human health and disease, with research indicating a strong association between gut microbial metabolism and the development and progression of coronary heart disease. This article provides a review of the relationship between gut microbiota and coronary heart disease, as well as the mechanisms by which traditional Chinese medicine regulates digestive tract microbiota to treat coronary heart disease, which systematically explains how the gut microbiota, through metabolic products and immune regulation, contributes to the occurrence and progression of coronary heart disease, and summarizes recent advances in research on traditional Chinese medicine’s regulation of gut microbiota for treating coronary heart disease. It aims to provide further reference and insights for exploring the relationship between gut microbiota and coronary heart disease, as well as traditional Chinese medicine approaches for treating coronary heart disease.

    關(guān)鍵詞:
    冠心病;腸道菌群;作用機制;治療;中藥

    Keywords:


    Project Supported:
    This study was supported by National Nature Science Foundation of China (No. 82374367), Jiangxi Provincial Natural Science Foundation (No. 20242BAB26163, 20232BAB206144), Jiangxi Provincial Traditional Chinese Medicine Research Project (No. 2023A0104), Jiangxi Province Key Laboratory of Traditional Chinese Medicine for Cardiovascular Diseases (No. 20242BCC32096), NATCM’s Project of High-level Construction of Key TCM Disciplines (No. zyyzdxk-2023113), Project of Key Discipline Construction Fund of Jiangxi University of Chinese Medicine (No. 2023jzzdxk032), Science and Technology Innovation Team Development Program of Jiangxi University of Chinese Medicine (No. CXTD22011), National Traditional Chinese Medicine Inheritance and Innovation Center Construction Project, Jiangxi Graduate student Innovation Special Fund Project (No. YC2023-S782). Thanks for the copyright support from Figdraw Software.

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