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Archive > Volume 17 Issue 3 > 2025,17(3):488-499. DOI:https://doi.org/10.1016/j.chmed.2025.02.003 Prev Next

決明子中的蒽醌類物質(zhì)通過調(diào)節(jié)棕色脂肪組織和肝臟功能，來緩解肥胖引起的脂質(zhì)堆積問題

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Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function

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    摘要:
    目的：決明子是一種廣泛應(yīng)用的傳統(tǒng)中藥，具有多種藥理作用。本研究旨在探究決明子中蒽醌類化合物（AQS）對肥胖的潛在治療效果及其分子機(jī)制。方法：研究采用高效液相色譜法（HPLC）測定了AQS的主要成分，隨后利用網(wǎng)絡(luò)藥理學(xué)分析預(yù)測了AQS潛在的抗肥胖作用靶點(diǎn)。通過構(gòu)建高脂高糖水飲食誘導(dǎo)的肥胖小鼠，觀察其體重變化和全身脂質(zhì)代謝情況，從而評估AQS在促進(jìn)脂質(zhì)代謝方面的潛在藥理作用。隨后，對比冷刺激前后棕色脂肪組織（BAT）表皮溫度差異，檢測肝臟和BAT組織中脂代謝相關(guān)基因的表達(dá)，以明確AQS的作用機(jī)制。結(jié)果：。網(wǎng)絡(luò)藥理學(xué)分析結(jié)果表明，AQS參與調(diào)控肥胖癥過程中肝臟和脂肪組織功能。病理生化結(jié)果表明，AQS能減少不健康飲食引起的肝臟和脂肪組織的脂質(zhì)積累。然而，AQS增加 BAT 的體積和重量，增強(qiáng)了小鼠的耐寒能力，表明AQS可促進(jìn)以 BAT 為主導(dǎo)的機(jī)體產(chǎn)熱。BAT組織中解偶聯(lián)蛋白1（UCP1）介導(dǎo)的適應(yīng)性產(chǎn)熱和肝臟脂質(zhì)代謝相關(guān)基因的水平在AQS治療也有所升高，進(jìn)一步證明了AQS可激活BAT產(chǎn)熱功能，促進(jìn)全身脂質(zhì)代謝。結(jié)論：該研究為AQS通過調(diào)節(jié)BAT產(chǎn)熱和肝臟脂質(zhì)代謝以緩解肥胖癥提供了科學(xué)依據(jù)，并為進(jìn)一步探索天然活性成分在代謝性相關(guān)疾病中的應(yīng)用提供了線索。

    Abstract:
    Objective: Cassiae Semen (CS, Juemingzi in Chinese) is a widely used traditional Chinese medicine with a variety of pharmacological effects. This study aimed to investigate the potential therapeutic effects and molecular mechanisms of anthraquinones of CS (AQS) for adiposity. Methods: The chemical components of the AQS were determined using high-performance liquid chromatography (HPLC). Network pharmacology analysis was used to predict potential anti-obesity targets of action for AQS. We constructed high fat with high sugar water diet-induced obese mice and observed their body weight and whole-body lipid metabolism to evaluate the efficacy of AQS in promoting lipid metabolism. Subsequently, the epidermal temperature at the brown adipose tissue (BAT) before and after cold stimulation was observed and the expression of lipid metabolism-related genes in the liver and BAT tissues was detected to clarify the mechanism of action of AQS. Results: Network pharmacology analysis showed that AQS was involved in the regulation of liver and adipose tissue function under obesity. Pathological and biochemical results showed that AQS reduced lipid accumulation in the liver and adipose tissue induced by an unhealthy diet. With the increase of cold tolerance, the volume and weight of BAT were increased by AQS, suggesting that it regulated the body heat production dominated by BAT. After AQS treatment, the levels of genes related to uncoupling protein1 (UCP1) mediated adaptive thermogenesis in BAT tissues and lipid metabolism in the liver were also increased, which further proved that AQS activated BAT function to promote lipid metabolism in the whole body. Conclusion: This study revealed the pharmacological effects of AQS, thereby providing a scientific basis for regulating BAT thermogenesis and liver lipid metabolism to alleviate obesity and providing clues for further exploring the application of natural active ingredients in the treatment of metabolismrelated diseases.

    關(guān)鍵詞:
    肥胖;蒽醌類化合物;棕色脂肪組織;決明子;肝臟;脂質(zhì)代謝;產(chǎn)熱作用

    Keywords:


    Project Supported:
    This work was supported by grants from the Fundamental Research Funds for the Central Universities (No. 2023-JYB-JBZD-046); National Key Research, Development Program on Modernization of Traditional Chinese Medicine (No. 2022YFC3502100); the National High-Level Talents Special Support Program; High-level traditional Chinese medicine key subjects construction project of National Administration of Traditional Chinese Medicine-Chinese Medicine Epidemic Disease (No. zyyzdxk-2023264).

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