腫柄菊來源于菊科腫柄菊屬植物，主要化學成分是倍半萜內(nèi)酯，還含有黃酮、色原酮、色原烯以及二萜、蒽醌和神經(jīng)酰胺等。腫柄菊的藥理作用主要有抗炎、抗瘧、抗腫瘤、降血糖以及其他一些活性。對近年來腫柄菊的倍半萜、色原烯等化學成分以及抗瘧、抗炎、降血糖等藥理活性做簡要綜述。

Most antipyretic-analgesic and anti-inflammatroy drugs are COX-2 inhibitors. There is a huge market for antipyretic-analgesic and anti-inflammatory drugs. Although these drugs have some toxic and side effects, there is no better substitute for them. After the discovery of mPGES-1, rescarchers pay much attention to this novel target, and have done many studies on biochemical and pathophysiological as pects of mPGES-1. Nevertheless the strdies on pharmaceutical aspect of mPGES-1 are still in the intitial stage. It is promising to developing new mPGES-1 inhibitors.

上海市科學技術(shù)委員會資助項目（08DZ1971503）；國家自然科學基金項目（20872177）