180乙醇提取物30%乙醇洗脫部位(Pft-d)的抗癌活性。方法 通過在體抗腫瘤實(shí)驗(yàn)和體外細(xì)胞毒實(shí)驗(yàn)，考察Pft-d對小鼠S180肉瘤、肝癌Heps腫瘤生長的抑制作用、對荷瘤小鼠免疫器官質(zhì)量的影響及其細(xì)胞毒活性。結(jié)果 Pft-d對小鼠S180、Heps腫瘤的生長均有明顯的抑制作用，劑量為10、20、40 mg/(kg·d)時，對S180肉瘤生長的抑制率分別為44.44%、52.14%、61.97%，對肝癌Heps生長的抑制率分別為34.64%、41.55%、56.03%，與對照組比較差異顯著(P＜0.005，P＜0.01、P＜0.001)。對荷瘤小鼠免疫器官無明顯影響。在體外，Pft-d高劑量時，對胃竇癌、胃癌、殘骨癌等人癌細(xì)胞顯示細(xì)胞毒活性，但低劑量時活性不明顯。結(jié)論 Pft-d具有強(qiáng)的抗癌活性，值得進(jìn)一步研究。;Objective To study the antitumor activity of Pft-d from 180) and Heps were observed. The effects of Ptf-d on immune organs of tumor-bearing mice were also studied. Results At the doses of 10, 20, and 40 mg/(kg·d), the inhibitory rates of Pft-d on S180 were 44.44%, 52.14%, and 61.97% respectively, and the inhibitory rates on Heps were 34.64%, 41.55%, and 56.03% respectively. There were significant differences in the inhibitory rates between control group and expermental group (P＜0.05, P＜0.01, P＜0.001). However, there was no obvious effect on the immune organs of tumor-bearing mice. In vitro studies showed that high dose of Pft-d did not show obvious cell toxic effects. Conclusion Pft-d has significant antitumor activities on S180 and Heps, and worthy of further study."/> 180肉瘤;肝癌Heps;細(xì)胞毒活性;Picria fel-terrae Lour; antitumor;sarcoma 180;Heps;cell toxicity"/>

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首頁 > 過刊瀏覽>2010年第25卷第2期 >2010,25(2):134-137. DOI:10.7501/j.issn.1674-5515.[year].2.[sequence]
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苦草提取物Pft-d對小鼠S180肉瘤、肝癌Heps的抗癌作用及體外細(xì)胞毒活性實(shí)驗(yàn)研究

Study on antitumor activities of extracts Pft-d from Picria fel-terrae

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    [關(guān)鍵詞]
    [摘要]
    目的 研究苦草Pft-d對小鼠S180乙醇提取物30%乙醇洗脫部位(Pft-d)的抗癌活性。方法 通過在體抗腫瘤實(shí)驗(yàn)和體外細(xì)胞毒實(shí)驗(yàn)，考察Pft-d對小鼠S180肉瘤、肝癌Heps腫瘤生長的抑制作用、對荷瘤小鼠免疫器官質(zhì)量的影響及其細(xì)胞毒活性。結(jié)果 Pft-d對小鼠S180、Heps腫瘤的生長均有明顯的抑制作用，劑量為10、20、40 mg/(kg·d)時，對S180肉瘤生長的抑制率分別為44.44%、52.14%、61.97%，對肝癌Heps生長的抑制率分別為34.64%、41.55%、56.03%，與對照組比較差異顯著(P＜0.005，P＜0.01、P＜0.001)。對荷瘤小鼠免疫器官無明顯影響。在體外，Pft-d高劑量時，對胃竇癌、胃癌、殘骨癌等人癌細(xì)胞顯示細(xì)胞毒活性，但低劑量時活性不明顯。結(jié)論 Pft-d具有強(qiáng)的抗癌活性，值得進(jìn)一步研究。
    [Key word]
    [Abstract]
    Objective To study the antitumor activity of Pft-d from Lour. Methods Experiments of in vitro cell toxicity and in vivo antitumor were conducted. The inhibitive effect of Pft-d on tumor growth of sarcoma 180 (180) and Heps were observed. The effects of Ptf-d on immune organs of tumor-bearing mice were also studied. Results At the doses of 10, 20, and 40 mg/(kg·d), the inhibitory rates of Pft-d on S180 were 44.44%, 52.14%, and 61.97% respectively, and the inhibitory rates on Heps were 34.64%, 41.55%, and 56.03% respectively. There were significant differences in the inhibitory rates between control group and expermental group (P＜0.05, P＜0.01, P＜0.001). However, there was no obvious effect on the immune organs of tumor-bearing mice. In vitro studies showed that high dose of Pft-d did not show obvious cell toxic effects. Conclusion Pft-d has significant antitumor activities on S180 and Heps, and worthy of further study.
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