目的 研究奈多羅米鈉合成的新方法。方法 以3-甲氧基苯胺為原料，經(jīng)酰化反應(yīng)、Friedel-Crafts反應(yīng)、克萊森重排、酯化合環(huán)等六步反應(yīng)得到終產(chǎn)物。結(jié)果 該合成方法操作簡(jiǎn)便，條件易控，收率較高。結(jié)論 該反應(yīng)路線為一條較為理想的奈多羅米鈉合成工藝路線。

Objective This study aims at developing a new method to synthesize nedocromil sodium. Methods In this experiment, 3-methoxyaniline was taken as the raw material, nedocromil sodium was obtained after a series of chemical reactions including acylation, Friedel-Crafts reaction, Claisen rearrangement, and esterification. Results The six-step synthesis is simple to operate and easy to control conditions, and yield high. Conclusion It is a desirable method for the synthesis of nedocromil sodium.