目的 觀察莧菜紅對實(shí)驗(yàn)大鼠的蓄積毒性，確定可能的毒副反應(yīng)靶器官，為深入研究提供參考。方法Wistar大鼠隨機(jī)分2組，分別為莧菜紅組和對照組。莧菜紅組采用劑量遞增方法給藥，即于第1～4天ig給予1/10LD50(LD50按10 g/kg計(jì)），以后每4 d按前一劑量0.5倍遞增1次，累計(jì)自實(shí)驗(yàn)開始至出現(xiàn)50%動物死亡期間的總劑量［∑LD(n)］；對照組給以蒸餾水。觀察實(shí)驗(yàn)期間大鼠的一般毒性癥狀、體質(zhì)量變化、死亡情況，進(jìn)行生化檢測，尸檢肉眼觀察器官病變。結(jié)果 實(shí)驗(yàn)期間動物的精神、外觀均無異常。體質(zhì)量、血液學(xué)、血液生化學(xué)等各項(xiàng)指標(biāo)均無明顯異常。結(jié)論 莧菜紅對動物無明顯蓄積毒性。

Objective To evaluate the toxic reactions of amaranth and determine the possible target organs so as to provide certain reference for further research. Methods Rats were divided randomly into two groups： amaranth group and control group. In amaranth group， rats were given orally different doses of amaranth increased continuously. In the first 1-4 days，the dose was one tenth of the LD50 dose (LD50 by 10 g/kg). Then the dose increased by 15 times once every 4 days until the death of 50% rats. The cumulative total dose (ΣLD50(n)) was obtained. Rats in control group were given distilled water. During the experiment，general toxic condition，body weight and death were observed，and biochemical tests were conducted. In addition， postmortem findings were also observed with naked eyes.ResultsDuring the experiment，there were no markedly abnormal changes in animal energy， appearance， body weight， hematological and blood biochemical parameters.Conclusion Amaranth does not show significant accumulative toxicity to animals.

中國檢驗(yàn)檢疫科學(xué)研究院院長基金項(xiàng)目(食品添加劑安全風(fēng)險評估研究)；中國質(zhì)檢總局課題(2009IK310)