摘 要：目的 探討藿香正氣軟膠囊治療功能性消化不良的作用機(jī)制。方法 采用夾尾致大鼠功能性消化不良模型進(jìn)行實(shí)驗(yàn)，觀察藿香正氣軟膠囊的療效。結(jié)果 藿香正氣軟膠囊明顯改善大鼠外觀癥狀，增加體質(zhì)量，增加胃電頻率，促進(jìn)胃排空及小腸推進(jìn)，對(duì)胃電幅度無明顯影響；明顯增加血清胃動(dòng)素及P物質(zhì)的量，明顯減少血管活性腸肽的量及NO的釋放，對(duì)生長(zhǎng)抑素?zé)o明顯影響。結(jié)論 藿香正氣軟膠囊通過增加胃動(dòng)素、P物質(zhì)，減少血管活性腸肽、NO的量達(dá)到促進(jìn)胃腸運(yùn)動(dòng)的目的。

Abstract: Objective To investigate the mechanism of Huoxiangzhengqi Soft Capsule in treatment of functional dyspepsia．Methods Cliping tail was used to establish experimental model of functional dyspepsia，then the therapeutic effects of Huoxiangzhengqi Soft Capsule on functional dyspepsia were observed and evaluated．Results Huoxiangzhengqi Soft Capsule improved significantly the appearance, increased body weight and gastric electrical frequency，promoted gastric emptying and intestinal propulsion，but it had no significant effect on gastric electrical amplitude．There was a remarkable increase in serum motilin and P substances in group of Huoxiangzhengqi soft capsule．Huoxiangzhengqi Soft Capsule also significantly reduced vasoactive intestinal polypeptide（VIP）content and NO releasing，and had no significant effect on secretion of somatostatin．Conclusion Huoxiangzhengqi Soft Capsule can promote the gastrointestinal motility by increasing secretion of motilin and P substances and reducing VIP and NO concentration．