摘 要：目的 比較氟伐他汀與辛伐他汀治療原發(fā)性高膽固醇血癥的成本和效果。方法 121例患者隨機(jī)分為A、B兩組，A組給以氟伐他汀，每次40 mg,每日1次，B組給以辛伐他汀，每次20 mg，每日1次，2組均連服6周。觀察給藥期間的不良反應(yīng)，并進(jìn)行成本-效果分析。結(jié)果 A、B組成本分別為1 250.96、1 357.22元，有效率分別為91.80%、90.00%（P＞0.05）,不良反應(yīng)發(fā)生率分別為5.8%、5.4%（P＞0.05）。結(jié)論 氟伐他汀和辛伐他汀均能降低患者血清總膽固醇、甘油三酯和低密度脂蛋白膽固醇水平，療效相似，且副作用小，安全性良好。從成本角度選擇，氟伐他汀為較佳治療方案。

Abstract: Objective To evaluate the cost-effectiveness of fluvastatin and simvastatin for treatment of primary hyperholesteromia．Methods A total of 121 patients with primary hyperholesteromia were randomly divided into group A and group B．Patients in group A were treated with 40 mg fluvastatin once each day for 6 weeks, and patients in group B were treated with 20 mg simvastatin once each day for 6 weeks．The side effects of fluvastatin and simvastatin were observed，and their cost-effectiveness were analyzed．Results For group A and group B，the cost of each patient was 1250.96 and 1357.22 Yuan per month，the total positive rate was 91.80% and 90.00%（P＞0.05），and the incidence of adverse reactions were 5.8% and 5.4%（P＞0.05）respectively． Conclusion Both fluvastatin and simvatatin can reduce the content of TC，TG，and LDL-C in patients with primary hypercholesterolemia．The two medicines have similar therapeutic effects and good safety，with little side effects．From the perspective of cost-effectiveness，fluvastatin is superior to simvatatin for treatment of primary hyperholesteromia．

中國(guó)檢驗(yàn)檢疫科學(xué)研究院院長(zhǎng)基金項(xiàng)目(食品添加劑安全風(fēng)險(xiǎn)評(píng)估研究)；質(zhì)檢總局課題(2009IK310)