摘 要：大黃酸是中藥蘆薈、大黃的主要成分之一，臨床上用于治療骨關(guān)節(jié)炎、糖尿病腎病等多種疾病，且具有協(xié)同抗腫瘤的作用。鑒于其較廣泛的藥理作用及低毒性、低成本等特點(diǎn)，大黃酸有望得到進(jìn)一步開發(fā)與應(yīng)用。綜述近幾年來對大黃酸及其衍生物在抗腫瘤、抗氧化、抗炎和對消化系統(tǒng)、腎臟、心血管系統(tǒng)、骨以及調(diào)脂等方面的藥理作用研究進(jìn)展。

Abstract: Rhein，a main constituent of Rhubarb，is a well-characterized anti-inflammatory agent which has been used for treatment of inflammatory diseases such as ostarthritis，diabetic nephropathy etc．It also has certain synergic antitumor effect．This paper reviews the recent studies on pharmacological actions，including anti-inflammation，anti-tumor，anti-oxidation，weight loss and lipid lowering of rhein and its derivatives．The effects of rhein and its derivatives on digestive system，kidney，heart，blood vessels and bone are also reviewed．

國家科技專項重大新藥創(chuàng)制“與藥效相關(guān)的中藥質(zhì)量評價關(guān)鍵技術(shù)研究”（200909502-021）