摘 要：目的 比較藿香正氣不同劑型產(chǎn)品以各自臨床用量的相同倍數(shù)給藥，其止瀉、止吐及解痙作用。方法 采用番瀉葉致小鼠腹瀉實(shí)驗(yàn)?zāi)Ｐ?，觀察單次量 ig 給藥后，小鼠的腹瀉潛伏期、腹瀉率、腹瀉級(jí)數(shù)及腹瀉指數(shù)；采用硫酸銅致家鴿嘔吐實(shí)驗(yàn)?zāi)Ｐ?，觀察單次量 ig 給藥后，家鴿的嘔吐潛伏期、嘔吐次數(shù)及嘔吐持續(xù)時(shí)間；采用甲硫酸新斯的明致小鼠小腸痙攣實(shí)驗(yàn)?zāi)Ｐ?，觀察單次量 ig 給藥后，炭末推進(jìn)百分率。結(jié)果 藿香正氣不同劑型產(chǎn)品均有不同程度的止瀉作用；藿香正氣膠囊、藿香正氣軟膠囊均有明顯的止吐作用；藿香正氣膠囊、藿香正氣軟膠囊、藿香正氣滴丸均有明顯的解痙作用。結(jié)論 藿香正氣膠囊作用最強(qiáng)，藿香正氣軟膠囊次之，不同廠家的產(chǎn)品作用強(qiáng)度有差異。

Abstract: Objective To compare the antidiarrheal，antiemetic and antispasmodic effects of different formulations of Huoxiang Zhengqi．Methods The diarrhea model of mice was induced by senna，and the incubation period，diarrhea rate，diarrhea progression and diarrhea index of mice were observed．The vomiting model of pigeon was induced by copper sulfate，and the incubation period，vomiting time and duration were observed．The mice model of small intestinal spasm was induced by neostigmine metilsulfate，and the percentage of carbon was observed．Results Huoxiang Zhengqi samples of different forms had varying degrees of antidiarrheal effects；Huoxiang Zhengqi Capsule，soft capsule had significant antiemetic effects；Huoxiang Zhengqi Capsules，soft capsules，and dripping pills had obvious spasmolysis．Conclusion The effect of Huoxiang Zhengqi Capsules is strongest，soft capsule is stronger than other formulations，and the potency is different among different manufacturers．