摘 要：目的 對(duì)美愈偽麻的低共熔現(xiàn)象進(jìn)行研究，考察了不同制備工藝對(duì)美愈偽麻低共熔物形成及壓片的影響。方法 通過(guò)繪制二元和三元相圖確定愈創(chuàng)木酚甘油醚、鹽酸偽麻黃堿和氫溴酸右美沙芬2組分間的最低共熔點(diǎn)及3組分間的低共熔溫度。結(jié)果 愈創(chuàng)木酚甘油醚、鹽酸偽麻黃堿和氫溴酸右美沙芬3組分間存在低共熔現(xiàn)象，3組分的低共熔溫度為62.6 ℃。結(jié)論 通過(guò)對(duì)美愈偽麻低共熔現(xiàn)象的研究，為設(shè)計(jì)其合理制備工藝提供理論依據(jù)。

Abstract: Objective To study the eutectic phenomenon of guaifenesin，pseudoephedrine hydrochloride and dextromethorphan hydrobromide in compound preparation and to investigate the effect of preparation process on eutectics and tablet pressing．Methods The eutetic melting point between two-component mixture and the eutectic temperature of the compound were determined by the phase diagram of binary and ternary systems．Results There existed eutectic phenomenon among guaifenesin，pseudoephedrine hydrochloride and dextromethorphan hydrobromide．The eutectic temperature of the three-component mixture was 62.6 ℃．Conclusion This study of the eutectic phenomenon can provide certain reference to design a suitable craft to prepare dextromethorphan Hydrobromide，guaifenesin and pseudoephedrine hydrochloride pharmaceutics．

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