摘 要：目的 研究影響復方枳參膠囊提取效果的各種因素，確定最佳提取工藝。方法 采用正交試驗設計，以浸膏收率和槲皮素提取率為指標，考察回流提取時間（A）、乙醇體積分數（B）、提取次數（C）和乙醇用量[乙醇體積（mL）/藥材量（g），D]4個因素對提取效果的影響，優(yōu)選出復方枳參膠囊的提取工藝。結果 在所考察的4個因素中，對復方枳參膠囊提取效果的影響程度依次為：B＞D＞C＞A，即乙醇體積分數＞乙醇用量＞提取次數＞回流提取時間，確定出最佳提取工藝為 B2D3C2A3，即10倍于藥材量（g）的70%乙醇（mL），回流提取2次，每次2 h 為最佳提取工藝。結論 本實驗優(yōu)選出的提取工藝適用于復方枳參膠囊的提取。

Abstract: Objective To determine the best extraction technique by studying the different factors that might affect the extraction of Fufang Zhishen Capsules．Methods The orthogonality experiment was adopted in the study．Extraction rate of quercetin and the extractum rate were taken as indices．The effects of four factors on the extraction were studied，including reflux extraction time（A），volume grade of alcohol（B），extraction times （C），and alcohol volume（D）which was calculated by alcohol volume（mL）divided by the amount of materials （g）．On the basis of the study on the four factors，the extraction technique was optimized．Results The effects of the four factors were listed as follows：B＞D＞C＞A．The best extraction technique was described as B2D3C2A3．The amount of 70% alcohol was 10 times of the medicinal materials．There were total 2 times of reflux extraction with 2 hour in each time．Conclusion The optimized technique is suitable to the extraction of Fufang Zhishen Capsule．

福建省省屬科研院所公益類基本科研專項（2009R10017-4）