摘 要：目的 觀察仙珠膠囊對去卵巢大鼠骨密度（BMD）、骨代謝標志物的影響。方法 將去卵巢大鼠隨機分為模型組，仙珠膠囊低、中、高劑量（2.715 、5.430、10.860 g生藥/kg）組及陽性藥倍美力片（0.104 mg/kg）組。另設假手術組。連續(xù)ig給藥3個月，測定血清中骨源性堿性磷酸酶（BALP）、Ⅰ型膠原交聯(lián)羧基末端肽（CTX）、雌二醇（E2）、甲狀旁腺素（PTH）、鈣（Ca）、磷（P）的量，并剖取大鼠股骨測BMD。結果 模型組大鼠BMD，E2、Ca、P的量低于假手術組（P<0.01）；各給藥組的這些指標高于模型組（P<0.05），高劑量仙珠膠囊組大鼠BMD高于陽性對照藥（P<0.05）。模型組大鼠BALP、CTX、PTH高于假手術組（P<0.01），仙珠膠囊及倍美力組這3項指標均降低（P<0.01）。結論 仙珠膠囊可有效增加去卵巢大鼠BMD，有效抑制骨丟失，增加成骨細胞活性，降低血清PTH水平，提高性激素水平。

Abstract: Objective To observe the effect of Xianzhu Capsula on bone mineral density (BMD), bone metabolic indicators of ovariectomized rats. Methods Ovariectomized rats were divided into model group, Xianzhu Capsula lower, middle, and high dose (2.715, 5.430, and 10.860 g raw meterials/kg) groups, Premarin Tablets (0.104 mg/kg) group, and Sham group. The rats were ig administrated medicine continuously for three months. The bone alkaline phosphatase (BALP), collagen cross-linked carboxy-terminal peptide (CTX), estradiol (E2) , PTH ,Ca, and P in serum were detected; Meanwhile, thigh bones were dissected to measure BMD. Results BMD, E2, Ca ,and P content of the model rats were all significantly lower than those in Sham group (P<0.01), while those indicators of Premarin Tablets group and Xianzhu Capsula group were higher than those of model rats (P<0.05) , and BMD in high dose group of Xianzhu Capsula was higher than that in Premarin Tablets group (P<0.05). BALP, CTX, and PTH of model rats were all significantly higher than those in Sham group (P<0.01). BALP, CTX, and PTH in Premarin Tablets group and Xianzhu Capsula group decreased (P<0.01). Conclusion Xianzhu Capsula could obviously elevate BMD of ovariectomized rats and effectively improve hyper-transform statement. Meanwhile, it could decrease PTH and inhibit bone loss, and stimulate osteoblast activity and elevate gonadal hormone level.