DLL4-Notch信號傳遞在人體組織的發(fā)育過程和細胞間通訊中發(fā)揮關鍵作用，其中包括調控細胞命運，調節(jié)細胞遷移、分化和增殖。最近的研究已經證實，在多種腫瘤細胞系中存在Notch基因的異常表達，且DLL4-Notch信號與腫瘤細胞的生長調控密切相關，因此該信號通路成為腫瘤診斷與治療的新靶點。簡要介紹DLL4-Notch信號傳遞系統的組成，以及國外關于DLL4-Notch信號傳遞途徑在抗腫瘤、調節(jié)血管生成與調節(jié)淋巴網絡形成等方面最新的研究進展。

The DLL4-Notch signal transduction plays a key role in cell development and cell-cell communication in vertebrates and invertebrates, including the regulations of cell fate, migration, differentiation, and proliferation. Recent studies have shown that in many tumor cell lines, Notch genes were abnormally expressed and DLL4-Notch signaling was correlated with the regulation of tumor cells, so this pathway could provide potential new targets for the diagnosis and therapy of tumor. The latest researches about the DLL4-Notch pathway in antitumor, angiogenesis, and lymphopoiesis abroad in recent years have been overviewed in this paper.

廣東省科技計劃項目（2010B030700044）；廣東省高等學校高層次人才項目