低密度脂蛋白經(jīng)氧化修飾后主要通過凝集素樣氧化低密度脂蛋白受體-1導(dǎo)致管內(nèi)皮細(xì)胞損傷，誘導(dǎo)黏附分子和炎癥因子的合成與釋放，加重血管炎癥反應(yīng)，誘導(dǎo)內(nèi)皮細(xì)胞凋亡，進(jìn)而導(dǎo)致動(dòng)脈粥樣硬化等心血管疾病。中藥復(fù)方通過抑制低密度脂蛋白(LDL)氧化生成氧化低密度脂蛋白（OX-LDL），防治血管內(nèi)皮損傷，進(jìn)而防治動(dòng)脈粥樣硬化的發(fā)生與發(fā)展。綜述近年來有關(guān)OX-LDL損傷血管內(nèi)皮細(xì)胞功能的機(jī)制，及具有抗OX-LDL損傷作用的、腦心通、冠心合劑、血脈脂康膠囊、通心絡(luò)、六味地黃方,黃連解毒湯等中藥復(fù)方的研究進(jìn)展。

Oxidized low density lipoprotein (OX-LDL) results the endothelial damage via lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) inducing the synthesis and release of adhesion molecules and proinflammatory cytokines, aggravating the vascular inflammation, and causing the endothelial cells apoptosis so as to lead atherosclerosis and some other cardiovascular diseases. Chinese medicinal formulae could prevent the endothelial injury by inhibiting that low density lipoprotein (LDL) was oxidized to OX-LDL, so as to block the occurance and development of atherosclerosis. The recent progress in research on the mechanism of OX-LDL-induced endothelial cell dysfunction and the related Chinese Traditional Medical Formulae with anti-OX-LDL function, such as Naoxintong, Guanxin Decoction, Xuemaizhikang Capsula, Tongxinluo, Liuwei Dihuang, and Huanglian Jiedu Decoction etc.