[關鍵詞]
[摘要]
脂肪乳作為一種給藥載體,不論處方組成還是制備工藝已經(jīng)日益成熟。SolEmul技術給油水均難溶藥物的制劑帶來希望;自乳化給藥系統(tǒng)可提高難溶性藥物的生物利用度;陽離子脂肪乳不僅延長藥物體內(nèi)循環(huán)時間,還使肺部給藥技術得到長足發(fā)展;同時脂肪乳在細胞靶向和中藥制劑的研究中也呈現(xiàn)出獨特的優(yōu)勢。隨著載藥脂肪乳各項研究的深入和發(fā)展,未來應用范圍必將更加廣泛。
[Key word]
[Abstract]
As a drug carrier, lipid emulsion has become increasingly mature regardless the prescription composition or preparation methods. SolEmul technology brings hope to insoluble drugs in oil and water; self-emulsifying drug delivery system can improve the bioavailability of the insoluble drugs; cationic lipid emulsion not only extends the drug circulation time, but also greatly develops the pulmonary drug delivery technology; while lipid emulsion has also shown a distinct advantage in cell targeting studies and Chinese medicine formulations. As the drug-loaded lipid emulsion is in-depth study and development, the future will be having more wide range of applications.
[中圖分類號]
[基金項目]
國家重點基礎研究發(fā)展計劃項目(2010CB735602);天津市科技支撐項目(09ZCKFSH01200)