甘草酸是甘草的有效成分，其選擇性誘導(dǎo)成熟的T淋巴細(xì)胞凋亡，調(diào)節(jié)淋巴細(xì)胞數(shù)量和功能，糾正外周血T淋巴細(xì)胞亞群的紊亂，具有抗炎、抗變態(tài)反應(yīng)的藥理作用；其機制為抑制抗體（IgG、IgE）生成，多靶點地抑制補體系統(tǒng)，抑制炎性細(xì)胞因子和炎癥介質(zhì)生成，以及對抗炎癥介質(zhì)的致炎作用。綜述了近年來國內(nèi)外對甘草酸及其衍生物抗炎、抗變態(tài)反應(yīng)的藥理作用及其機制的研究進展。

Glycyrrhizic acid, a bioactive constituent from Glycyrrhizae Radix et Rhizoma, selectively induces mature T lymphocyte apoptosis, modulates quantity and function of lymphocytes, and corrects disorder of T lymphocytic subgroups in circular blood. Glycyrrhizic acid possesses the efficacy against inflammation and allergy. Its mechanisms were counted as that glycyrrhizic acid inhibited the production of antibodies (IgG and IgE), and complement system by acting on multi-target; glycyrrhizic acid also could inhibit the production of inflammatory cytokines and inflammatory mediator, and antagonizes inflammatory reaction of inflammatory mediator. Research advances on pharmacological actions and mechanisms against inflammation and allergy of glycyrrhizic acid and its derivatives are reviewed in this paper.