三尖杉屬植物是主要的抗癌藥用植物，三尖杉堿類化合物是其主要活性成分，主要來源于植物組織培養(yǎng)、化學合成、內(nèi)生真菌等手段。這些生物堿有很強的抗腫瘤作用，其機制主要有抑制蛋白基因的表達、誘導細胞分化和凋亡等；因藥理作用比較明顯，臨床上用于急、慢性白血病以及紅斑狼瘡等疾病的治療。對三尖杉堿類化合物的來源和藥理作用及臨床應用方面的研究進展進行綜述。

The plants in Cephalotaxus Sieb. et Zucc. are very important medicinal plants with the significant anticancer activity. They have cephalotaxines as main alkaloids which can be obtained by many kinds of ways, such as plant tissue culture, chemical synthesis, and by means of endophytic fungi as well. These alkaloids have strong antitumor effect and the main mechanisms of them are inhibitory protein gene expression and induction of the cell differentiation and apoptosis. Because of their obvious pharmacological effects, they could be used to treat the patients with the acute and chronic diseases such as leukemia and lupus erythematosus in clinic. In this paper the recent progresses in the research of chemical resourse, pharmacological activities and clinical applications of the cephalotaxines are reviewed.