目的 探討木姜葉柯總黃酮對(duì)大小鼠血糖和糖耐量的影響。方法 采用遺傳性高血糖小鼠、四氧嘧啶誘發(fā)高血糖小鼠模型、鏈脲菌素誘發(fā)大鼠高血糖模型，觀察木姜葉柯總黃酮對(duì)大小鼠血糖和糖耐量的影響。結(jié)果 與模型組比較，木姜葉柯總黃酮低、中、高劑量（50、100、200 mg/kg）給藥，明顯降低遺傳性高血糖小鼠的空腹血糖（P＜0.05）；顯著降低四氧嘧啶誘發(fā)高血糖小鼠的空腹血糖（P＜0.05），同時(shí)能顯著改善其糖耐量（P＜0.05）。木姜葉柯總黃酮低、中、高劑量（30、60、120 mg/kg）給藥明顯降低鏈脲菌素誘發(fā)高血糖大鼠的空腹血糖（P＜0.05）并能顯著改善高血糖大鼠糖耐量（P＜0.05）。結(jié)論 木姜葉柯總黃酮能顯著改善高血糖大小鼠的血糖水平和糖耐量，提示其可用于糖尿病的治療。

Objective To study the effects of total flavonoids from Lithocarpus litseifolius on blood sugar level and glucose tolerance in rats and mice. Methods Hereditary hyperglycemic mice, alloxan-induced hyperglycemic mice, Streptozotocin-induced rat model with hyperglycemia were used to observe the impact of total flavonoids from L. litseifolius on blood sugar levels and glucose tolerance of rats and mice. Results Compared with the model group, the total flavonoids by administration at the low-, medium-, and high-dose (50, 100, and 200 mg/kg) could significantly lower the fasting blood sugar level of hereditary hyperglycemic and alloxan-induced hyperglycemic mice, simultaneously improve their glucose tolerance considerably (P<0.05); While the total flavonoids by administration at the low-, medium-, and high-dose (30, 60, and 120 mg/kg) could significantly reduce fasting blood sugar level in Streptozotocin-induced hyperglycemic rats (P<0.05) and improve their glucose tolerance remarkably (P<0.05). Conclusion The total flavonoids from L. litseifolius could significantly improve the blood sugar level and glucose tolerance in rats and mice with hyperglycemia. It suggests that the total flavonoids from L. litseifolius may be good for clinical treatment of diabetes.

廣西科學(xué)研究與技術(shù)開發(fā)計(jì)劃攻關(guān)項(xiàng)目（桂科攻0718002-2-13）