目的 對五味止痛片的處方進行優(yōu)化。方法 以顆粒的休止角、吸濕率、片芯硬度為指標，采用單因素試驗優(yōu)選五味止痛片的最佳處方。結(jié)果 優(yōu)選出最佳處方：以乳糖為填充劑，崩解劑乳糖、磷酸氫鈣、預膠化淀粉的比例為2∶2∶1.5，使用92%乙醇作為濕潤劑，用量約為粉末的20%。結(jié)論 制得的五味止痛片表面光潔度、硬度符合薄膜包衣片工藝要求，工藝簡便可行，適宜工業(yè)化生產(chǎn)。

Objective To optimize the formula of Wuwei Zhitong Tablets Methods The best formula was optimized by single-factor test with repose angle, moisture absorption rate of the granula, and the hardness of tablets as indexes. Results The optimal formula was filling agent by using lactose, and the ratio of lactose, CaHPO4 and amylum pregelatinisatum as disintegrant with 2∶2∶1.5, the wetting agent was 92% ethanol with the 20% of total powder. Conclusion The tablets are smooth and glossy, and have optimum hardness in accordance with the requirement. The process is simple and valuable for industrial production.

國家重大新藥創(chuàng)制專項（2009ZX09103-443）