目的 拆方研究三物白散各藥味組合對(duì)“寒痰證”的祛痰作用，探討方中藥味配伍機(jī)制。方法 通過(guò)冰水浴和灌胃冰水的方法制備小鼠“寒痰證”模型，通過(guò)氣管酚紅排泌實(shí)驗(yàn)?zāi)Ｐ?，比較各組合的祛痰作用，并利用計(jì)算機(jī)輔助層級(jí)聚類分析，探討三物白散拆方后各藥味組合機(jī)制。結(jié)果 三物白散全方、巴豆配伍桔梗和巴豆配伍貝母具有顯著祛痰作用（P＜0.05），單用巴豆則無(wú)明顯祛痰作用。層級(jí)聚類結(jié)果顯示含巴豆與不含巴豆的組合為不同的作用類型，配伍巴豆的實(shí)驗(yàn)組祛痰作用明顯增強(qiáng)。結(jié)論 三物白散方中巴豆需配伍桔梗或貝母后表現(xiàn)出較強(qiáng)的祛痰作用。

Objective To study the expectorant effect on ‘cold sputum syndrome’ of different formula combinations of different ingredients in Sanwubai Powder through prescription-separated method and further to explore compatibility mechanism. Methods The ice-water bath and ig administration of ice-water were combined to make ‘cold sputum syndrome’ pharmacological model firstly, and then the expectorant effect of each group administrated with different formula combinations was compared by phenolsulfonphthalein excretion of mouse trachea. Finally, the compatibility mechanism of Sanwubai Powder was investigated using computer-assisted cluster analysis. Results Whole prescription group, groups of Crotonis Fructus compatibility with Platycodonis Radix and with Fritillariae Cirrhosae Bulbus appeared significant expectorant effects (P<0.05), while there was no significant effect to in single Crotonis Fructus group. Expectorant effects of groups with or without Crotonis Fructus were differentiated by hierarchical cluster method. It was the fact that effects of groups with Crotonis Fructus were significantly improved. Conclusion Effective expectorant effects could be exerted for Crotonis Fructus only by combination of either Platycodonis Radix or Fritillariae Cirrhosae Bulbus in different formula combinations of Sanwubai Powder.