目的 確定川赤芍、赤芍、白芍抑制脂多糖（LPS）誘導大鼠肺泡巨噬細胞NR8383過度激活的“藥效成分組”。方法 以川赤芍、赤芍、白芍不同提取物LC-MS圖譜峰面積及其抑制LPS誘導的NR8383細胞活力增強為基礎，采用偏最小二乘回歸法，對LC-MS圖譜和抑制細胞增殖的內在聯(lián)系進行譜效分析。結果 LC-MS圖上的X11、X6、X1、X2、X9、X3這6個成分組成的“藥效成分組”對川赤芍、赤芍、白芍抑制NR8383細胞增殖藥效的貢獻較大。結論 “藥效成分組”的研究顯示，同基源的赤芍、白芍在抑制LPS誘導的NR8383細胞增殖方面具有相同的化學成分（X1、X2、X9、X3），但同時也有某些成分（X11、X6）僅能在赤芍中檢測到，這提示不同的化學成分及含量差異可能是造成赤芍、白芍功效不同的物質基礎。

Objective To study the “effective components group”of Paeoniae Radix Rubra, Paeoniae Radix Veitchii, and Paeoniae Radix Alba in the inhibiting proliferation of NR8383, which was induced by lipopolysaccharide (LPS). Methods The inherent relationship between LC-MS fingerprint and proliferation inhibition with partial least squares regression were analysed, which were based on LC-MS fingerprint peak areas of all samples and the inhibiting of cell activity increase of NR8383 of Paeoniae Radix Rubra, Paeoniae Radix Veitchii, and Paeoniae Radix Alba. Results Effective components group consists of six peaks X11, X6, X1, X2, X9, and X3 of the fingerprint, which played the most inhabitation of NR8383 proliferation. Conclusion “Effective components group” indicates that Paeoniae Radix Rubra and Paeoniae Radix Alba with the same origin contain the common ingredients (X1, X2, X9, and X3) in the inhibiting proliferation of NR8383. However, X11 and X16 only can be detected in Paeoniae Radix Rubra, which can be considered as the different material basis in efficacy between Paeoniae Radix Rubra and Paeoniae Radix Alba.