類風濕性關節(jié)炎（rheumatoid arthritis，RA）、節(jié)段性腸炎（Crohn′s disease，CD）等疾病具有類似的發(fā)病機制。腫瘤壞死因子（tumor necrosis factor，TNF）在這些疾病的發(fā)生發(fā)展中具有非常重要的作用。TNF分子在細胞因子免疫調節(jié)網(wǎng)絡中位于中樞環(huán)節(jié)，是重要的炎癥介質，過量的TNF導致炎癥的發(fā)生。目前上市的TNF抑制劑種類繁多，治療效果顯著。然而隨著TNF抑制劑廣泛應用，這類藥物的安全性逐漸受到重視。本文綜述了TNF與疾病關系、上市的TNF蛋白抑制劑分子結構、臨床應用等方面，重點關注藥物潛在的不良反應，并對近期新型TNF抑制劑的研究開發(fā)進行總結。

The pathogenesis mechanisms of diseases like rheumatoid arthritis (RA), Crohn’s disease (CD) are quite similar. Tumor necrosis factor (TNF) is likely to be of fundamental importance on the generation and development and plays a key role on the cytokine immune network. High level of TNF could induce inflammation. There are some TNF inhibitors marketed or in research, and both of them had remarkable efficacy. Along with TNF inhibitors being widely used, it’s more important to concern about the safety profiles. Therefore, this article reviews the relationship between TNF and diseases, and five TNF protein inhibitors available through structures and clinical use, keeping eyes on their possible side effect and providing some new TNF inhibitors with bright future.