聚乳酸乙醇酸（PLGA）是生物可降解的聚合物，已取得了美國(guó)FDA的批準(zhǔn)，用于組織工程支架和藥物載體。由于其具有良好的生物相容性和生物可降解性，近20年來(lái)成為小分子藥物、蛋白質(zhì)和其他大分子（DNA、RNA或多肽類）化合物的緩釋控釋制劑研究的熱點(diǎn)。對(duì)于PLGA微球制劑的研究主要集中在疫苗類、激素類、抗生素類、抗腫瘤類、神經(jīng)營(yíng)養(yǎng)物質(zhì)類等藥物控釋制劑。主要介紹近5年來(lái)這些藥物微球的研究情況，為進(jìn)一步開發(fā)利用PLGA作為藥物載體提供參考。

Poly lactic-co-glycolic acid (PLGA) is a biodegradable polymer used to fabricate devices for drug delivery and tissue engineering scaffolds, and has been approved by the FDA in US. Its application in fabrication of devices for drug delivery, including small molecular drug, protein and other macromolecules (DNA, RNA or peptides) has become a hot spot of study in recent two decades for its good biodegradability, and biocompatibility. Most studies focused on controlled release microspheres of vaccine, hormone, antibiotics, anticancer agent, neurotrophic active substances, etc. This paper describes some studies on these controlled release microspheres in recent five years.