目的 研究雙氯芬酸鈉插層鎂鋁水滑石的制備及其性能。方法 先采用羥丙基-β-環(huán)糊精對雙氯芬酸鈉進(jìn)行增溶，再采用共沉淀法將雙氯芬酸鈉插入到鎂鋁水滑石層間，制備了含有少量羥丙基-β-環(huán)糊精的雙氯芬酸鈉插層鎂鋁水滑石。采用X射線衍射、紅外光譜、熱重–差熱和元素分析對材料進(jìn)行表征。結(jié)果 確定雙氯芬酸鈉插層鎂鋁水滑石已合成，化學(xué)式為Mg0.69Al0.31(OH)2(雙氯芬酸鈉)0.30?2.0H2O。結(jié)論 與雙氯芬酸鈉相比，雙氯芬酸鈉插層鎂鋁水滑石的緩釋性能有了大幅度地提高，并且體外釋放符合Bhaskar模型。

Objective To study the preparation of diclofenac sodium-Mg-Al-hydrotalcite and its properties. Methods Hydroxypropyl- β-cyclodextrin was applied to increasing the solubility of diclofenac sodium. Then diclofenac sodium was intercalated into the Mg-Al-hydrotalcite to form an organic and inorganic complex material by the method of co-precipitation. The complex materials were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric-differential thermal analysis (TG-DTA), and elemental analysis. Results The diclofenac sodium -Mg-Al-hydrotalcite was formed and its chemical formula was Mg0.69Al0.31(OH)2 (diclofenac sodium)0.30?2.0H2O. Conclusion Comparing with diclofenac sodium, sustained release of diclofenac sodium-Mg-Al-hydrotalcite is improved and the release profile in vitro fits Bhaskar distribution well.