目的 考察橄欖油對(duì)氟比洛芬和雙氯芬酸鈉透過(guò)大鼠腹部皮膚的作用。方法 以離體大鼠腹部皮膚為滲透屏障，采用擴(kuò)散池裝置，以預(yù)處理皮膚法考察橄欖油對(duì)藥物透過(guò)皮膚的影響。結(jié)果 橄欖油可有效促進(jìn)氟比洛芬的經(jīng)皮透過(guò)率，增滲倍數(shù)為2.11，但對(duì)雙氯芬酸鈉的經(jīng)皮透過(guò)率有抑制作用。結(jié)論 橄欖油能夠促進(jìn)氟比洛芬的經(jīng)皮滲透，可能歸因于其中油酸的存在，還可能含有某些成分對(duì)雙氯芬酸鈉的經(jīng)皮滲透有抑制作用。

Objective To examine the effect of olive oil on percutaneous absorption of flubiprofen and diclofenac sodium in rats. Methods The rat skin was applied as barrier, and diffusion cell was used. Effects of olive oil on pretreatment of pretreated skin were studied. Results Olive oil could effectively enhance the permeation of flubiprofen with the enhancement ratio of 2.11, while it suppressed the percutaneous absorption of diclofenac sodium. Conclusion Olive oil could be an effective percutaneous absorption enhancer for flubiprofen because of its oleic acid, and its suppression for diclofenac sodium can also be worthy of exploitation.