目的 探討舍曲林聯(lián)合阿立哌唑治療強迫癥的臨床療效及耐受性。方法 86例強迫癥患者隨機分為觀察組（n = 43）和對照組（n = 43），觀察組用舍曲林和阿立哌唑聯(lián)合治療，對照組單用舍曲林治療，觀察治療12周。于治療前、治療4周末、8周末、12周末分別用耶魯布朗強迫量表（Y-BOCS）評定強迫癥狀、用漢密爾頓焦慮量表（HAMA）評定焦慮癥狀、用副反應量表（TESS）評定治療4周末、8周末、12周末的藥物不良反應。結果 Y-BOCS總分治療前、治療4周末兩組間差異無統(tǒng)計學意義（P＞0.05），治療8周末、12周末兩組間差異有統(tǒng)計學意義（P＜0.05）；HAMA總分治療前兩組差異無統(tǒng)計學意義（P＞0.05），治療4周末、8周末、12周末差異均有統(tǒng)計學意義（P＜0.05）；治療4周末、8周末、12周末兩組間TESS總分差異均無統(tǒng)計學意義（P＞0.05）。結論 舍曲林聯(lián)合阿立哌唑治療強迫癥效果良好，不良反應無增加。

Objective To explore the clinical efficacy and tolerance of sertraline combined with aripiprazole in the treatment of obsessive compulsive disorder. Methods Eighty-six patients with obsessive compulsive disorder were randomly divided into observation group (n = 43) and control group (n = 43). The patients in observation group were treated with sertraline and aripiprazole, while the patients in the control group were treated with sertraline, then the two groups were treated and observed for 12 weeks. Before treatment and at the end of 4, 8, and 12 weeks treatment, the efficacy was assessed with Yale-Brow obsessive compulsive scale (Y-BOCS) and Hamilton rating scale for anxiety (HAMA). The adverse reactions were assessed with the treatment emergent symptoms scale (TESS) at the end of 4, 8, and 12 weeks treatment. Results There was no significant difference in total score of Y-BOCS between the two groups before treatment and after the end of 4 weeks treatment (P > 0.05), there was significant difference in total score of Y-BOCS at the end of 8 and 12 weeks treatment (P < 0.05). There was no significant difference in total score of HAMA between the two groups before treatment (P > 0.05); At the end of 4, 8, and 12 weeks treatment, total scores of HAMA were significantly different (P < 0.05); At the end of 4, 8, and 12 weeks treatment, TESS scores were not significantly different (P > 0.05). Conclusion Clinical observation of sertraline combined with aripiprazole in obsessive compulsive disorder is favorable, at the same time, there is no increase in adverse reactions.