pH值敏感型脂質(zhì)體表面修飾已成為脂質(zhì)體制劑的研究熱點，經(jīng)過表面修飾的pH值敏感型脂質(zhì)體進入人體后，在此特異性片段的介導(dǎo)下，被靶細胞識別，達到在靶細胞有針對性地釋放藥物和減少對機體正常組織損害的目的。對pH值敏感型脂質(zhì)體進行表面修飾的主要目的有3個：延長體循環(huán)時間、增強pH值敏感性和提高靶向性。主要從這3方面綜述近十年來pH值敏感型脂質(zhì)體表面修飾的研究進展，為pH值敏感型脂質(zhì)體表面修飾的進一步研究提供參考。

The surface-modified technology of pH-sensitive liposomes has become the hot topic in the research of liposomes preparation. The pH-sensitive liposomes after being surface-modified could be recognized by target cells in vivo mediated by the specific segments so as to targetedly release the drugs and reduce the damage to human normal tissues. The surface-modified technology has three main purposes: prolonging drug in vivo circulation duration, increasing the pH-sensibility, and enhancing the targeting. This paper reviews the recent ten-year progresses in the surface-modified technology of pH-sensitive liposomes on these three aspects, providing the reference for further study on the surface modification of pH-sensitive liposomes.