動物實驗研究證實甘草酸對缺血再灌注性、梗阻性、高血糖性、藥物性（如馬兜鈴酸、慶大霉素、順鉑、阿霉素、鎘等引起的）、變態(tài)反應(yīng)性腎損傷都有保護作用。臨床研究肯定了甘草酸在治療腎綜合征出血熱中的療效。已經(jīng)有一些報道稱甘草酸對慢性腎臟疾病、原發(fā)性干燥綜合征并腎小管酸中毒、阿昔洛韋致急性腎衰竭和防治心臟手術(shù)引起的缺血再灌注性腎損傷也有療效，但還需要其他研究在臨床上進一步證實。

It has been proved that glycyrrhizic acid (GA) possesses renal protection against ischemia-reperfusion-, obstruction-, hyperglycemia-, drug (i.e. aristolochic acid, gentamycin, cisplatin, adriamycin or cadmium)-, and allergy-induced renal injury by animal experiments. In clinical studies, the curative effect of GA on hemorrhagic fever with renal syndrome has been confirmed. GA has efficacy in the treatment of chronic renal disease, primary sjogren syndrome with renal tubular acidosis, Acyclovir-induced renal failure and renal ischemia-reperfusion injury after cardiac operation in some reports, but some further researches should be done in clinic in future.