吸入給藥是防治哮喘、慢性阻塞性肺疾病等呼吸道疾病的首選給藥方式。常見(jiàn)的吸入給藥制劑包括壓力定量吸入劑、干粉吸入劑和霧化吸入劑。吸入給藥有效的評(píng)價(jià)指標(biāo)為粒徑的測(cè)定，測(cè)定吸入制劑粒徑的方法主要有撞擊器法和光學(xué)儀器法。就目前吸入給藥制劑的優(yōu)點(diǎn)、劑型分類、體外評(píng)價(jià)和研究現(xiàn)狀等進(jìn)行綜述。

Inhalation administration is the first choice for the treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary diseases (COPD). In clinic, the most common used dosage forms for inhaled drug administration are pressurized metered-dose inhalation, dry powder inhalation, and atomizing inhalation. The in vitro effective evaluation index of inhalation is particle size, and the determination of particle size could be carried out with the impactors method and the optical instruments method. This review discusses the characteristic, classification, research status, and in vitro evaluation methods of inhalation preparation.

國(guó)家重大新藥創(chuàng)制專項(xiàng)（2011ZX09-401-009，2011ZX09201-101-19，2012ZX09105102）；天津市科技支撐項(xiàng)目（09ZCKFSH01200）