[關(guān)鍵詞]
[摘要]
由于血腦屏障的存在，血液中的藥物難以進(jìn)入中樞神經(jīng)系統(tǒng)。近些年研究表明，經(jīng)鼻腔給藥后，藥物可以繞過(guò)血腦屏障直接進(jìn)入腦部，而且其對(duì)機(jī)體的損傷和副作用都較小，因此經(jīng)鼻腦靶向給藥系統(tǒng)不斷受到更多人的關(guān)注。首先探討了藥物經(jīng)鼻入腦的通路及機(jī)制，并針對(duì)鼻腔給藥的不同影響因素提出了相應(yīng)的優(yōu)化方案，還介紹了腦靶向性的評(píng)價(jià)方法，為進(jìn)一步研究鼻腦靶向制劑提供了參考。
[Key word]
[Abstract]
The blood-brain barrier (BBB) limits the distribution of systemically administered therapeutics to the central nervous system (CNS). Recent researches found that intranasal administration was a non-invasive method of drug delivery which might bypass the BBB to allow therapeutic substances direct access to the CNS with little body injury and side effects. So the intranasal delivery to CNS has attracted people’s attention. This review focuses on the current understanding of the mechanisms and potential pathways underlying the intranasal delivery to the CNS, puts forward several methods to optimize the system considering the factors, and introduces the evaluation methods of brain targeting to propel the research of the system.
[中圖分類(lèi)號(hào)]
[基金項(xiàng)目]
中藥制藥過(guò)程新技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室開(kāi)放基金課題（SKL2010M0302）；北京中醫(yī)藥大學(xué)復(fù)方中藥制藥研究創(chuàng)新團(tuán)隊(duì)（2011-CXTD-13）；北京中醫(yī)藥大學(xué)自主課題項(xiàng)目（2011-JYBZZ-JS048，2011JYB22XS-063）
