固相萃取技術是一種在20世紀70年代初發(fā)展起來的樣品預處理分離富集技術，具有操作簡單、省時，易實現自動化等優(yōu)點，廣泛應用在制藥、食品、環(huán)境、商檢、化工等領域。固相萃取技術與高效液相色譜（HPLC）或液相色譜（LC）、質譜（MS）法等分離檢測手段聯(lián)用，從而實現樣品在線預處理，使其在組合化學、高通量篩選等藥學領域的應用日益增多。簡要介紹了固相萃取技術在化學藥、中藥及天然藥物、生物藥中的應用。

Solid phase extraction technology is a sample pretreatment and enrichment technology, developed in the early 1970s, with the advantages of simple procedure, short time, and easy automation, etc. It is widely used in the fields of pharmacy, food, environment, commercial inspection, chemical industry, and so on. Solid phase extraction technology, combined with the separation detection methods of high performance liquid chromatography (HPLC), liquid chromatography (LC), or mass spectrometry (MS), could accomplish the online sample pretreatment and increase its application in combinatorial chemistry and high flux screening of pharmacy. This review briefly introduces the application of solid phase extraction technology in pharmaceutical chemicals, traditional Chinese medicine, natural medicine, and biological medicine.