目的 研究黃芪甲苷衍生物他司曲洛對實(shí)驗(yàn)大鼠心衰模型的改善作用。方法 將實(shí)驗(yàn)大鼠冠脈前降支結(jié)扎導(dǎo)致心肌梗死，制造慢性心衰模型，動(dòng)物分為假手術(shù)組、模型組、受試藥組、陽性對照組，采用累積給藥法，研究他司曲洛的正性肌力效應(yīng)，根據(jù)+LVdp/dtmax確定受試藥與陽性藥作用的等效劑量（ED15）、中毒量、相對安全指數(shù)；采用等效劑量法，各給藥組連續(xù)3 d靜脈輸注給藥，通過血流動(dòng)力學(xué)、彩色多普勒超聲心動(dòng)圖、血?dú)夥治?，以及肺水腫測定，研究各藥物短期治療心衰大鼠的作用效果及特點(diǎn)。結(jié)果 他司曲洛的最大效應(yīng)劑量為2 mg/kg，可產(chǎn)生25%的最大效應(yīng)。在等效劑量下，他司曲洛靜脈輸注給藥3 d，可明顯增加-dp/dtmax，降低LVEDP，降低A峰值，增加E/A比值，并可明顯增加血氧分壓與血氧含量，可明顯減輕肺組織水腫。結(jié)論 他司曲洛對實(shí)驗(yàn)大鼠心衰治療具有良好的效果，可達(dá)到部分正性肌力藥物的作用強(qiáng)度，并可改善心衰大鼠心臟的舒張功能，減輕肺水腫，改善心衰時(shí)的呼吸癥狀。

Objective To study the effect of astragaloside IV derivative tasiquluo used in the treatment of heart failure in experimental rat model. Methods To establish the congestive heart failure (CHF) in rats induced by ligation of the coronary artery. The animals were divided into Sham, model, teste, and positive control groups. Cumulative medication was used to study the positive inotropic effects of tasiquluo. The equivalent dosage (ED15), toxic dosage, and relative safety index were determined according to +LVdp/dtmax. Each group was iv administered with the equivalent dosage for 3 d. The effects and features in the treatment of the heart failure in rats for the short term were investigated by hemodynamics, color Doppler ultrasound echocardiogram, blood gas analysis, and pulmonary edema determination. Results The maximum effective dosage of Tasiquluo was 2 mg/kg, and 25% of the maximum effect could be generated. With ED15 iv infusion of tasiquluo for 3 d, the -LVdp/dtmax was significantly increased and the LVEDP was reduced. While the value of A peak lowered and E/A ratio increased, arterial blood oxygen pressure and oxygen content increased. At the same time, the edema of the lung tissue was relieved. Conclusion Tasiquluo has the good effects on experimental rat model with heart failure, and the drug could reach the positive inotropic effects to some extent. In addition, Tasiquluo could improve the cardiac diastolic functions, reduce the pulmonary edema, and improve the respiratory symptoms in rats with heart failure.