目的 通過家兔單肺通氣模型，觀察小劑量氨溴索經(jīng)氧氣驅(qū)動霧化吸入對家兔單肺通氣時通氣側(cè)肺炎性反應(yīng)的影響。方法 將健康家兔隨機(jī)分為雙肺通氣組、單肺通氣組、靜脈注射氨溴索組、氧氣驅(qū)動霧化吸入氨溴索組。雙肺通氣組行雙肺通氣2 h，其余3組行右側(cè)肺通氣2 h。靜脈注射氨溴索組和氧氣驅(qū)動霧化吸入氨溴索組分別在右肺通氣前10 min靜注氨溴索15 mg/kg或采用自制裝置氧氣驅(qū)動霧化吸入氨溴索7.5 mg。比較各組通氣后右肺（通氣）支氣管肺泡灌洗液中TNF-α、IL-1β、IL-8、IL-10濃度的變化。結(jié)果 與單肺通氣組比較，靜脈注射氨溴索組組和氧氣驅(qū)動霧化吸入氨溴索組右肺灌洗液TNF-α、IL-1β、IL-8濃度明顯降低，IL-10濃度明顯升高（P＜0.01）；肺損傷評分明顯降低（P＜0.01）。結(jié)論 氨溴索小劑量氧氣驅(qū)動霧化吸入可有效地抑制家兔單肺通氣的通氣側(cè)肺內(nèi)炎性反應(yīng)。

Objective To investigate the effects of oxygen atomizing inhalation low-dose ambroxol on the inflammatory response to ventilatied lung undergoing one lung ventilation (OLV) in rabbit models. Methods Healthy rabbits were randomly divided into four groups (n=10), control (C), OLV, iv administered ambroxol (IA), and oxygen atomizing inhalation ambroxol (AIA) groups. Group C received the two-lung ventilation for 2 h and other groups received the right lung ventilation for 2 h ; groups IA and AIA received the iv ambroxol 15 mg/kg and oxygen atomizing inhalation ambroxol 7.5 mg for 10 min before the right-lung ventilation. Right tracheal fluid concentrations of TNF-α, IL-1β, IL-8, and IL-10 were determined and light microscopic evaluations were performed to get the lung injury score. Results Right tracheal fluid levels of TNF-α, IL-1β, and IL-8 were significantly decreased while IL-10 concentration was significantly increased as compared with the group OLV (P < 0.01). Lung injury scores were significantly lower in the group C. Conclusion Oxygen atomizing inhalation low-dose ambroxol could inhibit the inflammatory response to ventilatied lung undergoing OLV in rabbits.