目的 考察以乳糖、甘露醇為輔料對(duì)骨疏靈顆粒吸濕性和成型性的影響。方法 考察單一輔料和混合輔料對(duì)骨疏靈顆粒的成型性、吸濕性的影響，采用單因素試驗(yàn)優(yōu)選浸膏與輔料的配比。結(jié)果 綜合吸濕性、成型性和制粒難易程度，以浸膏與混合輔料（乳糖、甘露醇比例為4∶1）1∶2的比例防潮效果最好。結(jié)論 乳糖和甘露醇通過(guò)適當(dāng)配比能明顯降低骨疏靈顆粒的吸濕性，提高成型性。

Objective To study the influence of lactose and mannitol as excipients on formability and hygroscopicity of Gushuling Granule. Methods Effects of single and mixed excipients on formability and hygroscopicity of Gushuling Granule were studied and single factor test was carried out to optimize the ratio of extraction and excipients. Results The best damp-proofing excipients integrated with formability, hygroscopicity, and granulation difficulty degree were extraction-excipient (lactose-mannitol by 4:1 ratio) at 1:2 ratio. Conclusion Appropriate ratio of lactose-mannitol could reduce the hygroscopicity and improve the formability of Gushuling Granule.