目的 考察注射用頭孢西丁鈉與茵梔黃注射液在5%葡萄糖注射液中的配伍穩(wěn)定性。方法 采用高效液相色譜法（HPLC）測定頭孢西丁鈉與茵梔黃注射液配伍后4 h內(nèi)頭孢西丁和黃芩苷，并考察配伍后外觀、pH值及不溶性微粒的變化。結(jié)果 配伍后的液體在4 h內(nèi)的外觀、pH值無明顯改變，但不溶性微粒數(shù)逐漸增多，二者的含量均逐漸降低。結(jié)論 頭孢西丁鈉與茵梔黃注射液配伍后4 h內(nèi)不穩(wěn)定，不建議臨床配伍使用。

Objective To investigate the compatible stability of cefoxintin sodium for injection and Yinzhihuang Injection (a compound injection of Chinese materia medica) in 5% glucose injection. Methods high performance liquid chromatography (HPLC) was established for the quantitative determination of cefoxintin and baicalin within 4 h after the compatibility of cefoxintin sodium for injection and Yinzhihuang Injection, and the changes of solution color, pH value, and insoluble particles were observed. Results The solution color and pH value showed no obvious changes. But the contents of cefoxintin and baicalin as well as the insoluble particles were increased with the compatible time extending. Conclusion The solution is unstable within 4 h after the compatibility of cefoxintin sodium for injection and Yinzhihuang Injection. So it should not be used in the compatibility.